Intraoperative Assessment of High-Risk Thyroid Nodules Based on Electrical Impedance Measurements: A Feasibility Study

被引：5

作者：

Firoozabadi, Jalil Beheshti ^{[1
,2
]}

Mahdavi, Reihane ^{[2
,3
,4
]}

Shamsi, Khosro ^{[1
,2
]}

Ataee, Hossein ^{[2
,3
,4
,5
]}

Shafiee, Abdollah ^{[2
,6
]}

Ebrahiminik, Hojat ^{[7
,8
,9
]}

Chegini, Hossein ^{[2
,9
]}

Hoseinpour, Parisa ^{[2
,10
]}

Moradi, Afshin ^{[11
]}

Yousefpour, Narges ^{[1
,3
,4
]}

Aghaei, Faeze ^{[1
,3
,4
]}

Fardoost, Ali ^{[1
]}

Ghelichli, Alireza ^{[1
,3
,4
]}

Dowlatabad, Hadi Mokhtari ^{[2
,3
,4
]}

Hajighasemi, Farzane ^{[2
,3
,4
]}

Sami, Nafiseh ^{[12
]}

Miri, Seyed Rouhollah ^{[3
,4
]}

Akbari, Mohammad Esmaeil ^{[1
]}

Abdolahad, Mohammad ^{[1
,2
,3
,4
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran 1416634793, Iran

[2] Univ Tehran, Fac Engn, Sch Elect & Comp Engn, Nano Bioelect Devices Lab, Tehran 1439957131, Iran

[3] Univ Tehran, Canc Elect Res Ctr, Tehran 1419733141, Iran

[4] Univ Tehran Med Sci, Imam Khomeini Hosp, Tehran 1419733141, Iran

[5] Amirkabir Univ Technol, Dept Elect Engn, Tehran 1591634311, Iran

[6] Farmanieh Hosp, Dept Surg, Tehran 1953734411, Iran

[7] Aja Univ Med Sci, Dept Internent Radiol, Tehran 1411718541, Iran

[8] Aja Univ Med Sci, Radiat Sci Res Ctr, Tehran 1411718541, Iran

[9] Tirad Imaging Inst, Intervent Radiol Dept, Tehran 1586736513, Iran

[10] ACECR, Motamed Canc Inst, Breast Canc Res Ctr, Dept Pathol, Tehran 1517964311, Iran

[11] Shahid Beheshti Univ Med Sci, Shohada Hosp, Dept Pathol, Tehran 1416634793, Iran

[12] Islamic Azad Univ Med Sci, Dept Med, Tehran 193951495, Iran

来源：

DIAGNOSTICS | 2022年 / 12卷 / 12期

关键词：

electrical impedance spectroscopy; fine needle aspiration; thyroid nodule; atypia of undetermined significance (AUS); impedance phase slope (IPS); surgery; CANCER; COMPLICATIONS; MALIGNANCY; MANAGEMENT; SURGERY;

D O I：

10.3390/diagnostics12122950

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Precise diagnosis of thyroid nodules is challenging due to non-diagnostic/inconclusive results and uncertainties about the malignancy of follicular neoplasms (FNs), even in frozen-section pathology. Therefore, surgical management, especially in Bethesda III and IV categories, may be complicated, and sometimes a second surgery may be required. The Thyroid Nodule Impedance Measurement System (TN-IMS) consists of a metallic patch attached to submental skin and a G20 I.V. cannula inserted into the targeted nodules. Two impedance-based parameters named Z(1kHz) and impedance phase slope (IPS) in 100 kHz to 500 kHz of the thyroid nodules are recorded and compared with their histopathological results as the gold standard. TN-IMS was intra-surgically applied to 103 human thyroid nodules and normal thyroid tissues. A remarkable consistency between defined co-ranges of Z(1kHz)/IPS and the histopathological status of specimens was achieved (p < 0.001). Based on these measurements, it was concluded that intraoperative bioelectrical impedance scanning of thyroid nodules would be a helpful complementary approach to detecting high-risk excision-required thyroid nodules.

引用

页数：11

共 32 条

[1] Thyroid Cancer Screening in South Korea Increases Detection of Papillary Cancers with No Impact on Other Subtypes or Thyroid Cancer Mortality [J].