A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans

被引：34

作者：

Kobayashi, Shiro ^{[1
]}

Ohmae, Masashi ^{[1
]}

Ochiai, Hirofumi ^{[1
]}

Fujikawa, Shun-ichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2006年 / 12卷 / 23期

关键词：

enzyme catalysis; glycosaminoglycans; hyaluronidase; polymerization;

D O I：

10.1002/chem.200600191

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hyaluronidase (HAase) catalyzes multiple enzymatic polymerizations with controlling regio- and stereoselectivity perfectly. This behavior, that is, the single enzyme being effective for multireactions and retaining the enzyme catalytic specificity, is not usual, and hence, HAase is a supercatalyst. Various sugar oxazoline monomers prepared based on the concept "transition-state analogue substrate" were successfully polymerized and copolymerized with HAase catalysis, yielding natural and unnatural glycosaminoglycans.

引用

页码：5962 / 5971

页数：10

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