A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans

被引：34
|
作者：
Kobayashi, Shiro [1 ]
Ohmae, Masashi [1 ]
Ochiai, Hirofumi [1 ]
Fujikawa, Shun-ichi [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2006年 / 12卷 / 23期
关键词：
enzyme catalysis; glycosaminoglycans; hyaluronidase; polymerization;
D O I：
10.1002/chem.200600191
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hyaluronidase (HAase) catalyzes multiple enzymatic polymerizations with controlling regio- and stereoselectivity perfectly. This behavior, that is, the single enzyme being effective for multireactions and retaining the enzyme catalytic specificity, is not usual, and hence, HAase is a supercatalyst. Various sugar oxazoline monomers prepared based on the concept "transition-state analogue substrate" were successfully polymerized and copolymerized with HAase catalysis, yielding natural and unnatural glycosaminoglycans.
引用
收藏
页码：5962 / 5971
页数：10
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