The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

被引：3
作者：
Kirkbride, James B. [1 ]
机构：
[1] UCL, Div Psychiat, London W1W 7EJ, England
来源：
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY | 2014年 / 49卷 / 10期
基金：
英国惠康基金;
关键词：
Polygenic risk; Gene-environment interaction; Epidemiology; Schizophrenia; Psychiatric genetics; CHALLENGES; PSYCHOSIS;
D O I：
10.1007/s00127-014-0961-6
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.
引用
收藏
页码：1531 / 1534
页数：4
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