Indenone derivatives:: A novel template for peroxisome proliferator-activated receptor γ (PPARγ) agonists

被引：127

作者：

Ahn, Jin Hee

Shin, Mi Sik

Jung, Sun Ho

Kang, Seung Kyu

Kim, Kwang Rok

Rhee, Sang Dal

Jung, Won Hoon

Yang, Sung Don

Kim, Seung Jun

Woo, Joo Rang

Lee, Jeong Hyung

Cheon, Hyae Gyeong ^{[1
]}

Kim, Sung Soo

机构：

[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305600, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 15期

关键词：

D O I：

10.1021/jm060389m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.

引用

收藏

页码：4781 / 4784

页数：4

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