Epithelial Mesenchymal Transition Confers Properties of Stem Cells on Cancer Cells

被引：0
作者：
Yu Shuai-Shuai [1 ]
Ma Xiao-Juan [1 ]
Lin Bi-Hua [2 ]
Li Ji-Xia [2 ]
Zhou Ke-Yuan [1 ,2 ]
机构：
[1] Guangdong Med Coll, Guangdong Key Lab Med Mol Diagnost, Dongguan 523808, Peoples R China
[2] Guangdong Med Coll, Inst Biochem & Mol Biol, Dongguan 523808, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 41卷 / 07期
基金：
中国国家自然科学基金;
关键词：
EMT; CSC; sternness; drug resistance; BREAST-CANCER; SELF-RENEWAL; TGF-BETA; PHENOTYPE; HEDGEHOG; PROMOTES; EMT; METASTASIS; SNAIL; DIFFERENTIATION;
D O I：
10.3724/SP.J.1206.2013.00359
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The epithelial mesenchymal transition(EMT)confers mesenchymal properties, migration and invasion on epithelial cells which normally is polarized and interacts with basement membrane via its basal surface. Cancer stem cell is a small subset of stem-like cells which have the capacity for self-renewal and asymmetric cell division. They play an important role in cancer initiation and progression. In rencent years, some researches reveal that EMT, which is closely related tumor metastasis, can generate tumour cells with propreties of stem cells. We review here recent observations correlated with the mechanism of it and its significance to clinical therapy.
引用
收藏
页码：632 / 639
页数：8
相关论文
共 60 条
[1]   ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features [J].
Albino, Domenico ;
Longoni, Nicole ;
Curti, Laura ;
Mello-Grand, Maurizia ;
Pinton, Sandra ;
Civenni, Gianluca ;
Thalmann, George ;
D'Ambrosio, Gioacchino ;
Sarti, Manuela ;
Sessa, Fausto ;
Chiorino, Giovanna ;
Catapano, Carlo V. ;
Carbone, Giuseppina M. .
CANCER RESEARCH, 2012, 72 (11) :2889-2900
[2]   Doxorubicin in Combination with a Small TGFβ Inhibitor: A Potential Novel Therapy for Metastatic Breast Cancer in Mouse Models [J].
Bandyopadhyay, Abhik ;
Wang, Long ;
Agyin, Joseph ;
Tang, Yuping ;
Lin, Shu ;
Yeh, I-Tien ;
De, Keya ;
Sun, Lu-Zhe .
PLOS ONE, 2010, 5 (04)
[3]   RETRACTED: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells (Retracted article. See vol. 423, pg. 153, 2018) [J].
Bao, Bin ;
Wang, Zhiwei ;
Ali, Shadan ;
Kong, Dejuan ;
Li, Yiwei ;
Ahmad, Aamir ;
Banerjee, Sanjeev ;
Azmi, Asfar S. ;
Miele, Lucio ;
Sarkar, Fazlul H. .
CANCER LETTERS, 2011, 307 (01) :26-36
[4]   The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells [J].
Brabletz, Simone ;
Bajdak, Karolina ;
Meidhof, Simone ;
Burk, Ulrike ;
Niedermann, Gabriele ;
Firat, Elke ;
Wellner, Ulrich ;
Dimmler, Arno ;
Faller, Gerhard ;
Schubert, Joerg ;
Brabletz, Thomas .
EMBO JOURNAL, 2011, 30 (04) :770-782
[5]   p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs [J].
Chang, Chun-Ju ;
Chao, Chi-Hong ;
Xia, Weiya ;
Yang, Jer-Yen ;
Xiong, Yan ;
Li, Chia-Wei ;
Yu, Wen-Hsuan ;
Rehman, Sumaiyah K. ;
Hsu, Jennifer L. ;
Lee, Heng-Huan ;
Liu, Mo ;
Chen, Chun-Te ;
Yu, Dihua ;
Hung, Mien-Chie .
NATURE CELL BIOLOGY, 2011, 13 (03) :317-U296
[6]   LIM-homeobox transcription factor 1, alpha (LMX1A) inhibits tumourigenesis, epithelial-mesenchymal transition and stem-like properties of epithelial ovarian cancer [J].
Chao, Tai-Kuang ;
Yo, Yi Te ;
Liao, Yu-Ping ;
Wang, Yu-Chi ;
Su, Po-Hsuan ;
Huang, Tien-Shuo ;
Lai, Hung-Cheng .
GYNECOLOGIC ONCOLOGY, 2013, 128 (03) :475-482
[7]   Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion [J].
Chen, J. ;
Imanaka, N. ;
Chen, J. ;
Griffin, J. D. .
BRITISH JOURNAL OF CANCER, 2010, 102 (02) :351-360
[8]  
Chen YT, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0023237, 10.1371/journal.pone.0017876]
[9]   Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma [J].
Chiou, Guang-Yuh ;
Cherng, Jong-Yuh ;
Hsu, Han-Shui ;
Wang, Mong-Lien ;
Tsai, Chun-Ming ;
Lu, Kai-Hsi ;
Chien, Yueh ;
Hung, Shih-Chieh ;
Chen, Yi-Wei ;
Wong, Chiang-Ing ;
Tseng, Ling-Ming ;
Huang, Pin-I ;
Yu, Cheng-Chia ;
Hsu, Wen-Huh ;
Chiou, Shih-Hwa .
JOURNAL OF CONTROLLED RELEASE, 2012, 159 (02) :240-250
[10]   Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation [J].
Chiou, Shih-Hwa ;
Wang, Mong-Lien ;
Chou, Yu-Ting ;
Chen, Chi-Jen ;
Hong, Chun-Fu ;
Hsieh, Wang-Ju ;
Chang, Hsin-Tzu ;
Chen, Ying-Shan ;
Lin, Tzu-Wei ;
Hsu, Han-Sui ;
Wu, Cheng-Wen .
CANCER RESEARCH, 2010, 70 (24) :10433-10444
123456