Uptake of VIV ion of vanadocene dichloride by apo-transferrin investigated by ESR spectroscopy

被引：5

作者：

Nishida, Yuzo ^{[1
]}

Niinuma, Aki ^{[1
]}

Abe, Keita ^{[1
]}

机构：

[1] Yamagata Univ, Fac Sci, Dept Chem, Yamagata 9908560, Japan

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2009年 / 12卷 / 03期

关键词：

Vanadocene dichloride; Apo-transferrin; ESR spectra; Anticancer activity; COMPLEXES; BINDING; ORIGIN;

D O I：

10.1016/j.inoche.2008.12.009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The action mechanism of vanadocene dichloride, Cp(2)Vcl(2) (CP=eta(5)-C5H5), has been investigated by interaction with apo-transferrin and albumin for its promising antitumor activities. Our ESR spectral studies clearly showed that V-IV ion is readily transported from vanadocene chloride to transferrin, and the V-IV ions are captured at the Fe(III) binding sites of transferrin as a VO2+ form. We also observed that some binuclear VO2+ complexes can efficiently transport the VO2+ ions to the apo-transferrin. (C) 2008 Published by Elsevier B.V.

引用

页码：198 / 200

页数：3

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