CRISPR-Cas9, a new chance for somatic gene therapy

被引：6

作者：

Jordan, Bertrand ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, Hop Adultes Timone, Espace Eth Mediterraneen, EFS,CNRS,UMR ADES 7268, F-13385 Marseille 05, France

[2] CoReBio PACA, F-13288 Marseille 09, France

来源：

M S-MEDECINE SCIENCES | 2015年 / 31卷 / 11期

关键词：

D O I：

10.1051/medsci/20153111018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Targeted modification of genes ("gene editing") is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; however this technology has less controversial applications, notably for somatic gene therapy with already some striking demonstrations in animal systems. Because of its precision and relative ease of use, CRISPR can be expected to drive a revolution in gene therapy and to turn it into a more mainstream approach.

引用

页码：1035 / 1038

页数：4

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