Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus

被引：70

作者：

Deng, Wei ^{[1
]}

Chen, Weiwei ^{[1
]}

Zhang, Zhuoya ^{[1
]}

Huang, Saisai ^{[1
]}

Kong, Wei ^{[1
]}

Sun, Yue ^{[1
]}

Tang, Xiaojun ^{[1
]}

Yao, Genhong ^{[1
]}

Feng, Xuebing ^{[1
]}

Chen, WanJun ^{[2
]}

Sun, Lingyun ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China

[2] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, OPCB, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL IMMUNOLOGY | 2015年 / 161卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Umbilical cord-derived mesenchymal stem cells; Systemic lupus erythematosus; Macrophage; IL-6; M2; MACROPHAGES; TRANSPLANTATION; MICE; NEPHRITIS; CLASSIFICATION; POLARIZATION; PHENOTYPE; CRITERIA; COLITIS; BIOLOGY;

D O I：

10.1016/j.clim.2015.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human umbilical cord-derived mesenchymal stem cells (UCMSCs) show therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in functional polarization and phagocytosis in macrophages has been suggested in the pathogenesis of SLE. We found that macrophages from B6.MRL-Fas(lpr) mice exhibited lower level of CD206, the marker for alternatively activated macrophage (AAM, also called M2). In addition, the phagocytic activity of B6.MRL-Fas(lpr) macrophages was also decreased. UCMSC transplantation improved the proportion of CD206(+) macrophages and their phagocytic activity in B6.MRL-Fas(lpr) mice. Importantly, macrophages from SLE patients also showed lower expression of CD206 and reduced phagocytic activity, which were corrected by being co-cultured with UCMSCs in vitro and in SLE patients receiving UCMSC transplantation. Mechanistically, we demonstrated that IL-6 was required for the up-regulation of CD206 expression and phagocytic activity of UCMSC-treated SLE macrophages. Our results indicate that UCMSCs alleviate SLE through promoting CD206 expression and phagocytic activity of macrophages in an IL-6 dependent manner. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：209 / 216

页数：8

共 46 条

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