Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings

被引：28

作者：

Ohkubo, M ^{[1
]}

Nishimura, T ^{[1
]}

Honma, T ^{[1
]}

Nishimura, I ^{[1
]}

Ito, S ^{[1
]}

Yoshinari, T ^{[1
]}

Arakawa, H ^{[1
]}

Suda, H ^{[1
]}

Morishima, H ^{[1
]}

Nishimura, S ^{[1
]}

机构：

[1] Merck Res Labs, Banyu Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期

关键词：

anticancer agents; topoisomerase; indolocarbazole; substituent effects;

D O I：

10.1016/S0960-894X(99)00595-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drug, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J-107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3307 / 3312

页数：6

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