X-ray and conformational analysis of methyl 3-amino-2,3-dideoxy-α-D-arabino-hexopyranoside

被引：14

作者：

Dabrowska, A ^{[1
]}

Sikorski, A ^{[1
]}

Jacewicz, D ^{[1
]}

Chmurzynski, L ^{[1
]}

机构：

[1] Univ Gdansk, Dept Gen Chem, PL-80952 Gdansk, Poland

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 06期

关键词：

methyl; 3-amino-2.3-dideoxy-alpha-D-arabino-hexopyranoside; crystal structure; hydrogen bonds;

D O I：

10.1016/j.carres.2004.02.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure, conformation and configuration of methyl 3-amino-2,3-dideoxy-alpha-D-arabino-hexopyranoside (1) were confirmed by H-1 NMR, C-13 NMR and IR spectroscopy, as well as by optical rotation, The structure of the compound studied was also determined by single crystal X-ray crystallography at 293 K and refined to a final R = 0.0521 based on 1798 independent reflections. The title compound crystallized in the tetragonal space group P4(3) with a = 6.572(1)Angstrom, b = 6.572(l) Angstrom, c = 41.161(8) Angstrom, D-c = 1.324 Mg cm(-3) and V = 1777.8(5) Angstrom(3) for Z = 8. The packing arrangement in the unit cell displayed a stratified structure. Moreover. medium-strength N-H...O and O-H...O hydrogen bonds, which stabilized the 3-D structure Of compound I, were observed. (C) 2004 Published by Elsevier Ltd.

引用

页码：1195 / 1199

页数：5

共 17 条

[1] GENERAL DEFINITION OF RING PUCKERING COORDINATES [J].