The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review

被引：53
作者：
Dwivedi, Jaya [1 ]
Sharma, Swapnil [2 ]
Jain, Sonika [1 ]
Singh, Aarti [1 ]
机构：
[1] Banasthali Univ, Dept Chem, Banasthali 304022, Rajasthan, India
[2] Banasthali Univ, Dept Pharm, Banasthali 304022, Rajasthan, India
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 11期
关键词：
Combinatorial chemistry; medicinal chemistry; pharmacological activity; pharmacophore; pyrazole; QSAR; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLES; ANTICONVULSANT ACTIVITY; INHIBITORY-ACTIVITY; CHANNEL INHIBITORS; KINASE INHIBITORS; DIAZO-COMPOUNDS; DESIGN; DISCOVERY;
D O I：
10.2174/1389557517666170927160919
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
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收藏
页码：918 / 947
页数：30
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