The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review

被引：50
作者：
Dwivedi, Jaya [1 ]
Sharma, Swapnil [2 ]
Jain, Sonika [1 ]
Singh, Aarti [1 ]
机构：
[1] Banasthali Univ, Dept Chem, Banasthali 304022, Rajasthan, India
[2] Banasthali Univ, Dept Pharm, Banasthali 304022, Rajasthan, India
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 11期
关键词：
Combinatorial chemistry; medicinal chemistry; pharmacological activity; pharmacophore; pyrazole; QSAR; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLES; ANTICONVULSANT ACTIVITY; INHIBITORY-ACTIVITY; CHANNEL INHIBITORS; KINASE INHIBITORS; DIAZO-COMPOUNDS; DESIGN; DISCOVERY;
D O I：
10.2174/1389557517666170927160919
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
引用
收藏
页码：918 / 947
页数：30
相关论文
共 110 条
  • [1] One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling
    Ahmed, MSM
    Kobayashi, K
    Mori, A
    [J]. ORGANIC LETTERS, 2005, 7 (20) : 4487 - 4489
  • [2] Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents
    Ahn, JH
    Kim, HM
    Jung, SH
    Kang, SK
    Kim, KR
    Rhee, SD
    Yang, SD
    Cheon, HG
    Kim, SS
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (17) : 4461 - 4465
  • [3] Synthesis and anticonvulsant activity of novel quinazolin-4(3H)-one derived pyrazole analogs
    Alagarsamy, Veerachamy
    Saravanan, Govindaraj
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (04) : 1711 - 1722
  • [4] Synthesis and antimicrobial studies of novel derivatives of 4-(4-formy1-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents
    Allison, Devin
    Delancey, Evan
    Ramey, Hunter
    Williams, Conrad
    Alsharif, Zakeyah Ali
    Al-Khattabi, Hessa
    Ontko, Allyn
    Gilmore, David
    Alam, Mohammad A.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (03) : 387 - 392
  • [5] Synthesis and evaluation of electron-rich curcumin analogues
    Amolins, Michael W.
    Peterson, Laura B.
    Blagg, Brian S. J.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (01) : 360 - 367
  • [6] 2-(1H-Pyrazol-4-yl) acetic acids as CRTh2 antagonists
    Andres, Miriam
    Bravo, Monica
    Antonia Buil, Maria
    Calbet, Marta
    Castro, Jordi
    Domenech, Teresa
    Eichhorn, Peter
    Ferrer, Manel
    Gomez, Elena
    Lehner, Martin D.
    Moreno, Imma
    Roberts, Richard S.
    Sevilla, Sara
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (11) : 3349 - 3353
  • [7] Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists
    Atobe, Masakazu
    Naganuma, Kenji
    Kawanishi, Masashi
    Morimoto, Akifumi
    Kasahara, Ken-ichi
    Ohashi, Shigeki
    Suzuki, Hiroko
    Hayashi, Takahiko
    Miyoshi, Shiro
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (22) : 6064 - 6067
  • [8] Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors
    Atobe, Masakazu
    Maekawara, Naomi
    Kawanishi, Masashi
    Suzuki, Hiroko
    Tanaka, Eiichi
    Miyoshi, Shiro
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (07) : 2111 - 2116
  • [9] 3,4-DIPHENYL-1H-PYRAZOLE-1-PROPANAMINE ANTIDEPRESSANTS
    BAILEY, DM
    HANSEN, PE
    HLAVAC, AG
    BAIZMAN, ER
    PEARL, J
    DEFELICE, AF
    FEIGENSON, ME
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (02) : 256 - 260
  • [10] Bamoniri A, 2012, IRAN J CATAL, V2, P75
12345678910