Early treatment of Kallmann syndrome may prevent eunuchoid appearance and behavior

被引：3
作者：
Castaneyra-Perdomo, Agustin [1 ,2 ]
Castaneyra-Ruiz, Leandro [1 ,3 ]
Gonzalez-Marrero, Ibrahim [1 ]
Castaneyra-Ruiz, Agustin [2 ]
Gonzalez-Toledo, Juan M. [1 ]
Castaneyra-Ruiz, Maria [2 ]
Carmona-Calero, Emilia M. [1 ,2 ]
机构：
[1] Univ La Laguna, Fac Med, Dept Anat, Tenerife, Islas Canarias, Spain
[2] Inst Ciencias Puerto del Rosario, Fuerteventura, Islas Canarias, Spain
[3] Univ La Laguna, Fac Med, Dept Farmacol, Tenerife, Islas Canarias, Spain
来源：
MEDICAL HYPOTHESES | 2014年 / 82卷 / 01期
关键词：
ACCESSORY OLFACTORY-BULB; CANDIDATE GENE; LHRH NEURONS; SYSTEM; HYPOTHALAMUS; CHEMOSIGNALS; MOLECULES; ADHESION; AMYGDALA; REGION;
D O I：
10.1016/j.mehy.2013.11.011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Kallmann syndrome (KS) is a genetic disorder which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia due to olfactory bulb aplasia. KS treatment usually begins just before puberty, but brain sexual maturation occurs long before puberty normally at perinatal age. As brain cells implicated in the development of the olfactory and reproductive system have a rostral and a caudal origin, and the rostral origin is affected by aplasia in KS and the caudal origin does not seem to be affected, the early treatment of KS, as proposed in this paper, is to attain brain sexual maturation at the most appropriate age possible to prevent the eunuchoid behavior and appearance observed in KS. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：74 / 76
页数：3
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