Role of M3 receptor in aconitine/barium-chloride-induced preconditioning against arrhythmias in rats

被引：22

作者：

Liu, Yan ^{[1
]}

Du, Juan ^{[1
]}

Gao, Yang ^{[1
]}

Zhang, Yong ^{[1
]}

Cai, Ben-zhi ^{[1
]}

Zhao, Hua ^{[1
]}

Qi, Han-ping ^{[1
]}

Du, Zhi-min ^{[3
]}

Lu, Yan-jie ^{[1
,2
]}

Yang, Bao-feng ^{[1
,2
]}

机构：

[1] Harbin Med Univ, Dept Pharmacol, Harbin 150081, Peoples R China

[2] Biopharmaceut Key Lab Heilongjiang Prov Incubator, Harbin 150081, Peoples R China

[3] Harbin Med Univ, Dept Clin Pharmacol, Harbin 150081, Peoples R China

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2009年 / 379卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Aconitine; BaCl2; Ventricular arrhythmias; Muscarinic M-3 receptor; Preconditioning; PROTECTIVE MECHANISM; MULTIPLE SUBTYPES; BRIEF ISCHEMIA; RESISTANCE; HEARTS;

D O I：

10.1007/s00210-008-0376-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We demonstrated here that an initial treatment with aconitine- or barium-chloride-induced arrhythmias and resulted in reduced susceptibility of the heart to the induction of arrhythmias by a repeated drug treatment 24 h after the initial one, a delayed preconditioning cardioprotection. This delayed preconditioning was accompanied by enhanced expression of cardiac muscarinic M-3 receptor and abolished by M-3-selective antagonist. We conclude that muscarinic M-3 receptors might play an important role in conferring the pharmacological preconditioning against arrhythmias. This study thus expands our understanding of the cellular function and pathophysiological roles of muscarinic M-3 receptor and reconsolidates our view of cardioprotective effects of muscarinic M-3 receptor on myocardium.

引用

页码：511 / 515

页数：5

共 8 条

[1] Role of M3 receptor in aconitine/barium-chloride-induced preconditioning against arrhythmias in rats
Yan Liu
Juan Du
Yang Gao
Yong Zhang
Ben-zhi Cai
Hua Zhao
Han-ping Qi
Zhi-min Du
Yan-jie Lu
Bao-feng Yang
Naunyn-Schmiedeberg's Archives of Pharmacology, 2009, 379 : 511 - 515
[2] Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: A potential role of terfenadine
Liu, Baoxin
Li, Shuang
Su, Yang
Xiong, Mengting
Xu, Yawei
MOLECULAR MEDICINE REPORTS, 2014, 10 (06) : 3217 - 3226
[3] Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats
Sariahmetoglu, M
Cakici, I
Kanzik, I
PHARMACOLOGICAL RESEARCH, 1998, 38 (03) : 173 - 178
[4] The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases
Liu, Xinxing
Yu, Yi
Zhang, Haiying
Zhang, Min
Liu, Yan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (14)
[5] Pharmacological delayed preconditioning against ischaemia-induced ventricular arrhythmias:: effect of an adenosine A1-receptor agonist
Tissier, R
Souktani, R
de Curzon, OP
Lellouche, N
Henry, P
Giudicelli, JF
Berdeaux, A
Ghaleh, B
BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (07) : 1532 - 1538
[6] Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2)plays a crucial role in aconitine-induced arrhythmias
Fu, Min
Li, Ru-Xin
Fan, Li
He, Guo-Wei
Thornburg, Kent L.
Wang, Zhao
BIOCHEMICAL PHARMACOLOGY, 2008, 75 (11) : 2147 - 2156
[7] Reciprocal regulation between M3 muscarinic acetylcholine receptor and protein kinase C-ε in ventricular myocytes during myocardial ischemia in rats
Hang, Peng-zhou
Zhao, Jing
Wang, Yu-ping
Sun, Li-hua
Zhang, Yong
Yang, Li-li
Zhao, Na
Sun, Zhi-dan
Mao, Yu-ying
Du, Zhi-min
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 380 (05) : 443 - 450
[8] Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolin-3 expression
Hamaguchi, E.
Tanaka, K.
Tsutsumi, R.
Sakai, Y.
Fukuta, K.
Kasai, A.
Tsutsumi, Y. M.
European Review for Medical and Pharmacological Sciences, 2015, 19 (07) : 1285 - 1290

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