Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses

被引：18

作者：

Peng, Yousong ^{[1
,2
]}

Li, Xiaodan ^{[3
]}

Zhou, Hongbo ^{[4
]}

Wu, Aiping ^{[5
,6
,7
]}

Dong, Libo ^{[3
]}

Zhang, Ye ^{[3
]}

Gao, Rongbao ^{[3
]}

Bo, Hong ^{[3
]}

Yang, Lei ^{[3
]}

Wang, Dayan ^{[3
]}

Lin, Xian ^{[4
]}

Jin, Meilin ^{[4
]}

Shu, Yuelong ^{[3
]}

Jiang, Taijiao ^{[2
,5
,6
,7
]}

机构：

[1] Humanitas Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China

[2] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

[3] China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 100052, Peoples R China

[4] Huazhong Agr Univ, Coll Anim Sci & Med, Wuhan 430070, Peoples R China

[5] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[6] Peking Union Med Coll, Beijing 100005, Peoples R China

[7] Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

TO-PERSON TRANSMISSION; GENETIC EVOLUTION; DIVERSITY; VACCINES; SUBLINEAGES; PERSISTENCE; EMERGENCE; POULTRY; PROTEIN; EGYPT;

D O I：

10.1038/srep43566

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The highly pathogenic avian influenza (HPAI) H5N1 virus poses a significant potential threat to human society due to its wide spread and rapid evolution. In this study, we present a comprehensive antigenic map for HPAI H5N1 viruses including 218 newly sequenced isolates from diverse regions of mainland China, by computationally separating almost all HPAI H5N1 viruses into 15 major antigenic clusters (ACs) based on their hemagglutinin sequences. Phylogenetic analysis showed that 12 of these 15 ACs originated in China in a divergent pattern. Further analysis of the dissemination of HPAI H5N1 virus in China identified that the virus's geographic expansion was co-incident with a significant divergence in antigenicity. Moreover, this antigenic diversification leads to global antigenic complexity, as typified by the recent HPAI H5N1 spread, showing extensive co-circulation and local persistence. This analysis has highlighted the challenge in H5N1 prevention and control that requires different planning strategies even inside China.

引用

页数：11

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