Induced Pluripotency and Epigenetic Reprogramming

被引：72
作者：
Hochedlinger, Konrad [1 ,2 ]
Jaenisch, Rudolf [3 ,4 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Dept Stem Cell & Regenerat Biol, Howard Hughes Med Inst, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
[3] MIT, Whitehead Inst, Cambridge, MA 02142 USA
[4] MIT, Dept Biol, Cambridge, MA 02142 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2015年 / 7卷 / 12期
关键词：
EMBRYONIC STEM-CELLS; X-CHROMOSOME INACTIVATION; HUMAN SOMATIC-CELLS; NUCLEAR TRANSFER; SELF-RENEWAL; DEVELOPMENTAL REGULATORS; DNA METHYLATION; MATURE B; MOUSE; GENERATION;
D O I：
10.1101/cshperspect.a019448
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Induced pluripotency defines the process by which somatic cells are converted into induced pluripotent stem cells (iPSCs) upon overexpression of a small set of transcription factors. In this article, we put transcription factor-induced pluripotency into a historical context, review current methods to generate iPSCs, and discuss mechanistic insights that have been gained into the process of reprogramming. In addition, we focus on potential therapeutic applications of induced pluripotency and emerging technologies to efficiently engineer the genomes of human pluripotent cells for scientific and therapeutic purposes.
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页数：25
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