Hydrogels Constructed from Engineered Proteins

被引：71

作者：

Li, Hongbin ^{[1
]}

Kong, Na ^{[1
]}

Laver, Bryce ^{[1
]}

Liu, Junqiu ^{[2
]}

机构：

[1] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[2] Jilin Univ, Key Lab Supramol Struct & Mat, Changchun 130012, Jilin Province, Peoples R China

来源：

SMALL | 2016年 / 12卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ELASTIN-LIKE POLYPEPTIDE; CROSS-LINKING; FRAGMENT RECONSTITUTION; DRUG-DELIVERY; IN-SITU; MECHANICAL-PROPERTIES; CONFORMATIONAL-CHANGE; DESIGNING MATERIALS; CRYSTAL-STRUCTURE; BLOCK-COPOLYMERS;

D O I：

10.1002/smll.201502429

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to their various potential biomedical applications, hydrogels based on engineered proteins have attracted considerable interest. Benefitting from significant progress in recombinant DNA technology and protein engineering/design techniques, the field of protein hydrogels has made amazing progress. The latest progress of hydrogels constructed from engineered recombinant proteins are presented, mainly focused on biorecognition-driven physical hydrogels as well as chemically crosslinked hydrogels. The various bio-recognition based physical crosslinking strategies are discussed, as well as chemical crosslinking chemistries used to engineer protein hydrogels, and protein hydrogels' various biomedical applications. The future perspectives of this fast evolving field of biomaterials are also discussed.

引用

页码：973 / 987

页数：15

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