Expression of RNAs Coding for Metal Transporters in Blood of Patients with Huntington's Disease

被引：2

作者：

Szeliga, Monika ^{[1
]}

Rozycka, Aleksandra ^{[2
]}

Jedrak, Paulina ^{[3
]}

Baranska, Sylwia ^{[3
]}

Janik, Piotr ^{[4
,5
]}

Jamrozik, Zygmunt ^{[5
]}

Albrecht, Jan ^{[1
]}

机构：

[1] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurotoxicol, 5 Pawinskiego Str, PL-02106 Warsaw, Poland

[2] Warsaw Univ Life Sci, Fac Hort Biotechnol & Landscape Architecture, 166 Nowoursynowska Str, PL-02787 Warsaw, Poland

[3] Univ Gdansk, Dept Mol Biol, 59 Wita Stwosza Str, PL-80308 Gdansk, Poland

[4] Wolski Hosp Dr Anny Gostynskiej, Dept Neurol, 17 Kasprzaka Str, PL-01211 Warsaw, Poland

[5] Med Univ Warsaw, Dept Neurol, 1 Banacha Str, PL-02097 Warsaw, Poland

来源：

NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 1-2期

关键词：

Huntington's disease; Metal transporter; TF; TFR; DMT1; ZIP8; PARKINSONS-DISEASE; MANGANESE HOMEOSTASIS; MOLECULAR-MECHANISMS; MUTANT HUNTINGTIN; BASAL GANGLIA; IRON; BRAIN; GENE; DMT1; TRANSFERRIN;

D O I：

10.1007/s11064-015-1737-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have demonstrated elevated levels of iron (Fe) in brains of patients with Huntington's disease (HD). Striatal cells carrying mutated Huntingtin presented increased sensitivity to cadmium (Cd) toxicity, decreased sensitivity to manganese (Mn) toxicity and deficits in Mn uptake. The hypothesis arose that the observed alterations result from the altered expression and/or activity of proteins engaged in the transport of these metals, that is: transferrin (TF), transferrin receptor (TFR), divalent metal transporter 1 (DMT1) and ZIP8 protein. Here we examined the expression levels of genes encoding these proteins in blood of HD patients and control subjects. A decreasing tendency in the level of TF transcript and increasing tendency of SLC11A2 mRNA encoding DMT1 was observed in the blood of HD patients compared to the control subjects, but neither attained statistical significance. No changes were found in the levels of TFRC coding for TFR and SLC39A8 coding for ZIP8 between HD patients and controls. The results indicate that HD-associated changes in metal homeostasis occur are not related to mechanisms other than the expression level of the here analyzed metal transporters.

引用

页码：101 / 106

页数：6

共 42 条

[1] Manganese: Recent advances in understanding its transport and neurotoxicity [J].

Aschner, Michael ;

Guilarte, Tomas R. ;

Schneider, Jay S. ;

Zheng, Wei .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 221 (02) :131-147

[2]

Avila Daiana Silva, 2013, Met Ions Life Sci, V13, P199, DOI 10.1007/978-94-007-7500-8_7

[3] Increased basal ganglia iron levels in Huntington disease [J].

Bartzokis, G ;

Cummings, J ;

Perlman, S ;

Hance, DB ;

Mintz, J .

ARCHIVES OF NEUROLOGY, 1999, 56 (05) :569-574

[4] Myelin breakdown and iron changes in Huntington's disease: Pathogenesis and treatment implications [J].

Bartzokis, George ;

Lu, Po H. ;

Tishler, Todd A. ;

Fong, Sophia M. ;

Oluwadara, Bolanle ;

Finn, J. Paul ;

Huang, Danny ;

Bordelon, Yvette ;

Mintz, Jim ;

Perlman, Susan .

NEUROCHEMICAL RESEARCH, 2007, 32 (10) :1655-1664

[5] Early defect of transforming growth factor β1 formation in Huntington's disease [J].

Battaglia, Giuseppe ;

Cannella, Milena ;

Riozzi, Barbara ;

Orobello, Sara ;

Maat-Schieman, Marion L. ;

Aronica, Eleonora ;

Busceti, Carla Letizia ;

Ciarmiello, Andrea ;

Alberti, Silvia ;

Amico, Enrico ;

Sassone, Jenny ;

Sipione, Simonetta ;

Bruno, Valeria ;

Frati, Luigi ;

Nicoletti, Ferdinando ;

Squitieri, Ferdinando .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 15 (03) :555-571

[6] Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner [J].

Benn, Caroline L. ;

Sun, Tingting ;

Sadri-Vakili, Ghazaleh ;

McFarland, Karen N. ;

DiRocco, Derek P. ;

Yohrling, George J. ;

Clark, Timothy W. ;

Bouzou, Berengere ;

Cha, Jang-Ho J. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (42) :10720-10733

[7] Iron Accumulates in Huntington's Disease Neurons: Protection by Deferoxamine [J].

Chen, Jianfang ;

Marks, Eileen ;

Lai, Barry ;

Zhang, Zhaojie ;

Duce, James A. ;

Lam, Linh Q. ;

Volitakis, Irene ;

Bush, Ashley I. ;

Hersch, Steven ;

Fox, Jonathan H. .

PLOS ONE, 2013, 8 (10)

[8] Manganese homeostasis in the nervous system [J].

Chen, Pan ;

Chakraborty, Sudipta ;

Mukhopadhyay, Somshuvra ;

Lee, Eunsook ;

Paoliello, Monika M. B. ;

Bowman, Aaron B. ;

Aschner, Michael .

JOURNAL OF NEUROCHEMISTRY, 2015, 134 (04) :601-610

[9] An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity [J].

Cisbani, G. ;

Cicchetti, F. .

CELL DEATH & DISEASE, 2012, 3 :e382-e382

[10] ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE-METALS IN PARKINSONS-DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA [J].

DEXTER, DT ;

CARAYON, A ;

JAVOYAGID, F ;

AGID, Y ;

WELLS, FR ;

DANIEL, SE ;

LEES, AJ ;

JENNER, P ;

MARSDEN, CD .

BRAIN, 1991, 114 :1953-1975

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