Head and Neck Squamous Cell Carcinoma: Epigenetic Landscape

被引：28
作者：
Romanowska, Kamila [1 ,2 ]
Sobecka, Agnieszka [1 ,2 ]
Rawluszko-Wieczorek, Agnieszka A. [3 ]
Suchorska, Wiktoria M. [2 ]
Golusinski, Wojciech [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Head & Neck Surg, Greater Poland Canc Ctr, PL-61866 Poznan, Poland
[2] Poznan Univ Med Sci, Dept Med, Greater Poland Canc Ctr, Radiobiol Lab, PL-61866 Poznan, Poland
[3] Poznan Univ Med Sci, Dept Histol & Embryol, PL-60781 Poznan, Poland
来源：
DIAGNOSTICS | 2021年 / 11卷 / 01期
关键词：
head and neck cancer; squamous cell carcinoma; epigenetics; DNA methylation; histone modification; non-coding RNA activity; RNA methylation; biomarkers; TUMOR-SUPPRESSOR GENES; M(6)A RNA METHYLATION; WIDE DNA METHYLATION; HISTONE METHYLATION; PROMOTER METHYLATION; HUMAN-PAPILLOMAVIRUS; PROGNOSTIC-FACTOR; KAPPA-B; CANCER; EXPRESSION;
D O I：
10.3390/diagnostics11010034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Head and neck squamous carcinoma (HNSCC) constitutes the sixth most prevalent cancer worldwide. The molecular pathogenesis of HNSCC includes disorders in cell cycle, intercellular signaling, proliferation, squamous cell differentiation and apoptosis. In addition to the genetic mutations, changes in HNSCC are also characterized by the accumulation of epigenetic alterations such as DNA methylation, histone modifications, non-coding RNA activity and RNA methylation. In fact, some of them may promote cancer formation and progression by controlling the gene expression machinery, hence, they could be used as biomarkers in the clinical surveillance of HNSCC or as targets for therapeutic strategies. In this review, we focus on the current knowledge regarding epigenetic modifications observed in HNSCC and its predictive value for cancer development.
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页数：16
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共 140 条
  • [1] Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma:: Promoter hypermethylation with clinical correlation in 100 cases
    Ai, LB
    Quynh, NV
    Zuo, CL
    Li, LW
    Ling, WH
    Suen, JY
    Hanna, E
    Brown, KD
    Fan, CY
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2004, 13 (01) : 150 - 156
  • [2] Role of activated nuclear factor-κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
    Allen, Clint T.
    Ricker, Justin L.
    Chen, Zhong
    Van Waes, Carter
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2007, 29 (10): : 959 - 971
  • [3] NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)
    Almeida, Luciana O.
    Abrahao, Aline C.
    Rosselli-Murai, Luciana K.
    Giudice, Fernanda S.
    Zagni, Chiara
    Leopoldino, Andreia M.
    Squarize, Cristiane H.
    Castilho, Rogerio M.
    [J]. FEBS OPEN BIO, 2014, 4 : 96 - 104
  • [4] Clinical update on head and neck cancer: molecular biology and ongoing challenges
    Alsahafi, Elham
    Begg, Katheryn
    Amelio, Ivano
    Raulf, Nina
    Lucarelli, Philippe
    Sauter, Thomas
    Tavassoli, Mahvash
    [J]. CELL DEATH & DISEASE, 2019, 10 (8)
  • [5] Annunziato AT, 2000, GENE EXPRESSION, V9, P37
  • [6] Structure, function and evolution of CpG island promoters
    Antequera, F
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (08) : 1647 - 1658
  • [7] Head and neck cancer
    Argiris, Athanassios
    Karamouzis, Michalis V.
    Raben, David
    Ferris, Robert L.
    [J]. LANCET, 2008, 371 (9625) : 1695 - 1709
  • [8] Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma
    Arunkumar, Ganesan
    Rao, Arunagiri Kuha Deva Magendhra
    Manikandan, Mayakannan
    Rao, Harikrishnan Prasanna Srinivasa
    Subbiah, Shanmugam
    Ilangovan, Ramachandran
    Murugan, Avaniyapuram Kannan
    Munirajan, Arasambattu Kannan
    [J]. ONCOLOGY LETTERS, 2018, 15 (01) : 649 - 657
  • [9] LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma
    Ban, Yuanyuan
    Tan, Pingqing
    Cai, Jing
    Li, Junjun
    Hu, Meng
    Zhou, Ying
    Mei, Yan
    Tan, Yixin
    Li, Xiaoling
    Zeng, Zhaoyang
    Xiong, Wei
    Li, Guiyuan
    Li, Xiayu
    Yi, Mei
    Xiang, Bo
    [J]. MOLECULAR ONCOLOGY, 2020, 14 (06) : 1282 - 1296
  • [10] Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes
    Bannister, AJ
    Schneider, R
    Myers, FA
    Thorne, AW
    Crane-Robinson, C
    Kouzarides, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) : 17732 - 17736
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