CD 30-positive transformed follicular lymphoma: two case reports and literature review

被引：3

作者：

Montes-Moreno, Santiago ^{[1
,2
]}

Climent, Fina ^{[3
,4
]}

Gonzalez de Villambrosia, Sonia ^{[1
,2
]}

Gonzalez Barca, Eva M. ^{[3
,4
]}

Batlle, Ana ^{[1
,2
]}

Insunza, Andres ^{[1
,2
]}

Pane-Foix, Maria ^{[3
,4
]}

Colorado, Mercedes ^{[1
,2
]}

Martin-Sanchez, Guillermo ^{[1
,2
]}

Richard Espiga, Carlos ^{[1
,2
]}

Conde, Eulogio ^{[1
,2
]}

Piris, Miguel A. ^{[1
,2
]}

机构：

[1] Hosp Univ Marques Valdecilla, IDIVAL, Dept Pathol, Santander 39010, Cantabria, Spain

[2] Hosp Univ Marques Valdecilla, IDIVAL, Dept Hematol, Santander 39010, Cantabria, Spain

[3] Hosp Univ Bellvitge, ICO, Dept Pathol, Barcelona, Spain

[4] Hosp Univ Bellvitge, ICO, Dept Hematol, Barcelona, Spain

来源：

HISTOPATHOLOGY | 2015年 / 67卷 / 06期

关键词：

CD30-positive secondary diffuse large B cell lymphoma (DLBCL); FL transformation; intrafollicular neoplasia; B-CELL LYMPHOMA;

D O I：

10.1111/his.12733

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aims: Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. Results: The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immunoglobulin (Ig) H and cytogenetic identity was demonstrated between both components. High-dose and auto-stem cell transplant (SCT) was applied and complete response was achieved. The second case represents an example of d'emblee transformation of intrafollicular neoplasia to CD30-positive large B cell lymphoma. Immunoglobulin K deleting element (IgKde) and cytogenetic identity between both phases was demonstrated. The patient was in partial response after four cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Conclusions: CD30 expression was found to be associated in these cases to the transformation event and could be considered a therapeutic target to add to conventional immunochemotherapeutic regimens, even in combination with auto-SCT. We suggest looking for CD30 expression in transformed follicular lymphoma cases.

引用

页码：918 / 922

页数：5

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