On-Site and Quantitative Detection of Trace Methamphetamine in Urine/Serum Samples with a Surface-Enhanced Raman Scattering-Active Microcavity and Rapid Pretreatment Device

被引:38
作者
Fang, Wei [1 ,2 ,3 ]
Zhang, Biao [2 ]
Han, Fang-Yuan [4 ]
Qin, Zhang-Na [2 ]
Feng, Yu-Qi [2 ,5 ]
Hu, Ji-Ming [2 ]
Shen, Ai-Guo [1 ,2 ]
机构
[1] Wuhan Univ, Sch Printing & Packaging, Wuhan 430079, Peoples R China
[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430079, Peoples R China
[3] Ji Hua Lab, Lab Microwave & Vacuum Technol, Foshan 528000, Peoples R China
[4] Guangxi Power Grid Co Ltd, Elect Power Res Inst, Nanning 530023, Peoples R China
[5] Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Wuhan 430072, Peoples R China
基金
中国国家自然科学基金;
关键词
PERFORMANCE LIQUID-CHROMATOGRAPHY; GLYCOL DIMETHACRYLATE) MONOLITH; HUMAN URINE; GOLD NANOPARTICLES; DRUGS; ACID; IDENTIFICATION; CAPILLARY; SEPARATION; READOUT;
D O I
10.1021/acs.analchem.0c03041
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Here, it reports a high-throughput detection method for reliably quantitative analysis of illegal drugs in complex biological samples by means of a surface-enhanced Raman scattering (SERS) active microcavity and rapid pretreatment device. Based on the well-made hemispherical microcavities that regularly distributed on a glass array, the quality-controllable microcavity device is fabricated by the compact self-assembly of core-shell nanopeanuts (CSNPs) onto the inside surface. Both the CSNPs with a quantifiable internal standard signal of crystal violet acetate anchored inside their gap and the well-made microcavity referred to the physical amplification of the microscale groove surface will do well in trace analysis, which will allow us to realize the accurately quantitative SERS analysis of targeted analytes spread on the bottom area of the microcavity array. As an example, 0.8 nM malachite green and 160 ppb methamphetamine (MATM) have been successively detected in a wide range as standard, while even 0.01 ppm MATM mixed in the urine/serum samples has been efficiently tested by the microcavity device equipped with a rapid pretreatment device (manual monolithic column syringe needle). All of the above suggest that the SERS-active microcavity equipped with a rapid pretreatment device has potential in the on-site quick test of trace amounts of illegal drugs in bodily fluid samples or other field analysis of food sanitation, environmental safety, and public health.
引用
收藏
页码:13539 / 13549
页数:11
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