Functional MRI Reveals Compromised Neural Integrity of the Face Processing Network in Congenital Prosopagnosia

被引:119
作者
Avidan, Galia [1 ,2 ]
Behrmann, Marlene [3 ,4 ]
机构
[1] Ben Gurion Univ Negev, Dept Psychol, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, IL-84105 Beer Sheva, Israel
[3] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA
[4] Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA
关键词
TEMPORAL-LOBE ATROPHY; VENTRAL VISUAL-CORTEX; DEVELOPMENTAL PROSOPAGNOSIA; DETAILED EXPLORATION; CORTICAL NETWORK; PERCEPTION; FAMILIARITY; FMRI; RECOGNITION; ADAPTATION;
D O I
10.1016/j.cub.2009.04.060
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The summed activity of multiple nodes of a distributed cortical network supports face recognition in humans, including "core" ventral occipitotemporal cortex (VOTC) regions [1-3], and "extended" regions outside VOTC [4, 5]. Many individuals with congenital prosopagnosia-an impairment in face processing [6-9]-exhibit normal blood oxygenation level-dependent (BOLD) activation in the core VOTC regions [10, 11]. These individuals evince a reduction in the structural integrity of the white matter tracts connecting VOTC to anterior temporal and frontal cortices [12], part of the "extended" face network. The impairment in congenital prosopagnosia may arise, therefore, not from a dysfunction of the core VOTC areas but from a failure to propagate signals between the intact VOTC and the extended nodes of the network. Using the fMR adaptation paradigm with famous and unknown faces, we show that individuals with congenital prosopagnosia evince normal adaptation effects in VOTC, indicating sensitivity to facial identity, but show no differential activation for familiar versus unknown faces outside VOTC, particularly in the precuneus/posterior cingulate cortex and the anterior paracingulate cortex. Normal BOLD activation in VOTC is thus insufficient to subserve intact face recognition, and disrupted information propagation between VOTC and the extended face processing network may explain the functional impairment in congenital prosopagnosia.
引用
收藏
页码:1146 / 1150
页数:5
相关论文
共 50 条
  • [41] Generalized Recurrent Neural Network accommodating Dynamic Causal Modeling for functional MRI analysis
    Wang, Yuan
    Wang, Yao
    Lui, Yvonne W.
    NEUROIMAGE, 2018, 178 : 385 - 402
  • [42] Convolutional Recurrent Neural Network for Dynamic Functional MRI Analysis and Brain Disease Identification
    Lin, Kai
    Jie, Biao
    Dong, Peng
    Ding, Xintao
    Bian, Weixin
    Liu, Mingxia
    FRONTIERS IN NEUROSCIENCE, 2022, 16
  • [43] Neural processing of a cocaine-associated odor cue revealed by functional MRI in awake rats
    Johnson, Tehya R.
    Smerkers, Brian
    Moulder, Janelle K.
    Stellar, James R.
    Febo, Marcelo
    NEUROSCIENCE LETTERS, 2013, 534 : 160 - 165
  • [44] Testing EEG functional connectivity between sensorimotor and face processing visual regions in individuals with congenital facial palsy
    Quettier, Thomas
    Maffei, Antonio
    Gambarota, Filippo
    Ferrari, Pier Francesco
    Sessa, Paola
    FRONTIERS IN SYSTEMS NEUROSCIENCE, 2023, 17
  • [45] Use of connectotyping on task functional MRI data reveals dynamic network level cross talking during task performance
    Vazquez-Trejo, Valeria
    Nardos, Binyam
    Schlaggar, Bradley L.
    Fair, Damien A.
    Miranda-Dominguez, Oscar
    FRONTIERS IN NEUROSCIENCE, 2022, 16
  • [46] DeepRetroMoCo: deep neural network-based retrospective motion correction algorithm for spinal cord functional MRI
    Mobarak-Abadi, Mahdi
    Mahmoudi-Aznaveh, Ahmad
    Dehghani, Hamed
    Zarei, Mojtaba
    Vahdat, Shahabeddin
    Doyon, Julien
    Khatibi, Ali
    FRONTIERS IN PSYCHIATRY, 2024, 15
  • [47] Multi-Hops Functional Connectivity Improves Individual Prediction of Fusiform Face Activation via a Graph Neural Network
    Wu, Dongya
    Li, Xin
    Feng, Jun
    FRONTIERS IN NEUROSCIENCE, 2021, 14
  • [48] Functional MRI reveals activation of a subcortical network in a 5-year-old girl with genetically confirmed myoclonus-dystonia
    Nitschke, M. F.
    Erdmann, C.
    Trillenberg, P.
    Sprenger, A.
    Kock, N.
    Sperner, J.
    Klein, C.
    NEUROPEDIATRICS, 2006, 37 (02) : 79 - 82
  • [49] A Task-Optimized Neural Network Replicates Human Auditory Behavior, Predicts Brain Responses, and Reveals a Cortical Processing Hierarchy
    Kell, Alexander J. E.
    Yamins, Daniel L. K.
    Shook, Erica N.
    Norman-Haignere, Sam V.
    McDermott, Josh H.
    NEURON, 2018, 98 (03) : 630 - +
  • [50] Data-driven MRI analysis reveals fitness-related functional change in default mode network and cognition following an exercise intervention
    Lloyd, Katherine M.
    Morris, Timothy P.
    Anteraper, Sheeba
    Voss, Michelle
    Nieto-Castanon, Alfonso
    Whitfield-Gabrieli, Susan
    Fanning, Jason
    Gothe, Neha
    Salerno, Elizabeth A.
    Erickson, Kirk I.
    Hillman, Charles H.
    Mcauley, Edward
    Kramer, Arthur F.
    PSYCHOPHYSIOLOGY, 2024, 61 (04)