The summed activity of multiple nodes of a distributed cortical network supports face recognition in humans, including "core" ventral occipitotemporal cortex (VOTC) regions [1-3], and "extended" regions outside VOTC [4, 5]. Many individuals with congenital prosopagnosia-an impairment in face processing [6-9]-exhibit normal blood oxygenation level-dependent (BOLD) activation in the core VOTC regions [10, 11]. These individuals evince a reduction in the structural integrity of the white matter tracts connecting VOTC to anterior temporal and frontal cortices [12], part of the "extended" face network. The impairment in congenital prosopagnosia may arise, therefore, not from a dysfunction of the core VOTC areas but from a failure to propagate signals between the intact VOTC and the extended nodes of the network. Using the fMR adaptation paradigm with famous and unknown faces, we show that individuals with congenital prosopagnosia evince normal adaptation effects in VOTC, indicating sensitivity to facial identity, but show no differential activation for familiar versus unknown faces outside VOTC, particularly in the precuneus/posterior cingulate cortex and the anterior paracingulate cortex. Normal BOLD activation in VOTC is thus insufficient to subserve intact face recognition, and disrupted information propagation between VOTC and the extended face processing network may explain the functional impairment in congenital prosopagnosia.
机构:
NYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
Wang, Yuan
Wang, Yao
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h-index: 0
机构:
NYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
Wang, Yao
Lui, Yvonne W.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, CAI2R, New York, NY 10016 USA
NYU, Sch Med, Bernard & Irene Schwartz Ctr Biomed Imaging, 660 First Ave, New York, NY 10016 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Lin, Kai
Jie, Biao
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Jie, Biao
Dong, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Dong, Peng
Ding, Xintao
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Ding, Xintao
Bian, Weixin
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Bian, Weixin
Liu, Mingxia
论文数: 0引用数: 0
h-index: 0
机构:
Univ North Carolina Chapel Hill, Dept Radiol, Chapel Hill, NC 27514 USA
Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr BR, Chapel Hill, NC 27514 USAAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
机构:
Rush Med Coll, Chicago, IL USA
Portland State Univ, Dept Biol, Portland, OR USARush Med Coll, Chicago, IL USA
Vazquez-Trejo, Valeria
Nardos, Binyam
论文数: 0引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR USA
Washington Univ, Dept Occupat Therapy, Sch Med St Louis, St Louis, MO USARush Med Coll, Chicago, IL USA
Nardos, Binyam
Schlaggar, Bradley L.
论文数: 0引用数: 0
h-index: 0
机构:
Kennedy Krieger Inst, Baltimore, MD USA
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA
Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD USARush Med Coll, Chicago, IL USA
Schlaggar, Bradley L.
Fair, Damien A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Masonic Inst Developing Brain, Minneapolis, MN 55455 USA
Univ Minnesota, Inst Child Dev, Coll Educ & Human Dev, Minneapolis, MN USARush Med Coll, Chicago, IL USA
Fair, Damien A.
Miranda-Dominguez, Oscar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Masonic Inst Developing Brain, Minneapolis, MN 55455 USA
Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USARush Med Coll, Chicago, IL USA
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Kell, Alexander J. E.
Yamins, Daniel L. K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Psychol, Stanford, CA USA
Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA
Stanford Neurosci Inst, Stanford, CA USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Yamins, Daniel L. K.
Shook, Erica N.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Shook, Erica N.
Norman-Haignere, Sam V.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Norman-Haignere, Sam V.
McDermott, Josh H.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USA
Harvard Univ, Program Speech & Hearing Biosci & Technol, Cambridge, MA 02138 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
机构:
Northeastern Univ, Boston, MA USA
Northeastern Univ, Dept Psychol, 675 ISEC,805 Columbus Ave, Boston, MA 02120 USANortheastern Univ, Boston, MA USA
Lloyd, Katherine M.
Morris, Timothy P.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Morris, Timothy P.
Anteraper, Sheeba
论文数: 0引用数: 0
h-index: 0
机构:
Carle Illinois Adv Imaging Ctr, Urbana, IL USANortheastern Univ, Boston, MA USA
Anteraper, Sheeba
论文数: 引用数:
h-index:
机构:
Voss, Michelle
Nieto-Castanon, Alfonso
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Nieto-Castanon, Alfonso
Whitfield-Gabrieli, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Whitfield-Gabrieli, Susan
Fanning, Jason
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Univ, Winston Salem, NC USANortheastern Univ, Boston, MA USA
Fanning, Jason
Gothe, Neha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA
Gothe, Neha
Salerno, Elizabeth A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ St Louis, St Louis, MO USANortheastern Univ, Boston, MA USA
Salerno, Elizabeth A.
Erickson, Kirk I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Pittsburgh, PA USA
Univ Granada, PROFITH PROmoting FITness & Hlth Phys Act Res Grp, Granada, Spain
AdventHealth Res Inst, Neurosc Inst, Orlando, FL USANortheastern Univ, Boston, MA USA
Erickson, Kirk I.
Hillman, Charles H.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USA
Northeastern Univ, Dept Phys Therapy Movement & Rehabil Sci, Boston, MA USANortheastern Univ, Boston, MA USA
Hillman, Charles H.
Mcauley, Edward
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA
Mcauley, Edward
Kramer, Arthur F.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USA
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA
机构:
NYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
Wang, Yuan
Wang, Yao
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
Wang, Yao
Lui, Yvonne W.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, CAI2R, New York, NY 10016 USA
NYU, Sch Med, Bernard & Irene Schwartz Ctr Biomed Imaging, 660 First Ave, New York, NY 10016 USANYU, Tandon Sch Engn, NYU WIRELESS, 6 MetroTech Ctr, Brooklyn, NY 11201 USA
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Lin, Kai
Jie, Biao
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Jie, Biao
Dong, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Dong, Peng
Ding, Xintao
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Ding, Xintao
Bian, Weixin
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R ChinaAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
Bian, Weixin
Liu, Mingxia
论文数: 0引用数: 0
h-index: 0
机构:
Univ North Carolina Chapel Hill, Dept Radiol, Chapel Hill, NC 27514 USA
Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr BR, Chapel Hill, NC 27514 USAAnhui Normal Univ, Sch Comp & Informat, Wuhu, Peoples R China
机构:
Rush Med Coll, Chicago, IL USA
Portland State Univ, Dept Biol, Portland, OR USARush Med Coll, Chicago, IL USA
Vazquez-Trejo, Valeria
Nardos, Binyam
论文数: 0引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR USA
Washington Univ, Dept Occupat Therapy, Sch Med St Louis, St Louis, MO USARush Med Coll, Chicago, IL USA
Nardos, Binyam
Schlaggar, Bradley L.
论文数: 0引用数: 0
h-index: 0
机构:
Kennedy Krieger Inst, Baltimore, MD USA
Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA
Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD USARush Med Coll, Chicago, IL USA
Schlaggar, Bradley L.
Fair, Damien A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Masonic Inst Developing Brain, Minneapolis, MN 55455 USA
Univ Minnesota, Inst Child Dev, Coll Educ & Human Dev, Minneapolis, MN USARush Med Coll, Chicago, IL USA
Fair, Damien A.
Miranda-Dominguez, Oscar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Masonic Inst Developing Brain, Minneapolis, MN 55455 USA
Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USARush Med Coll, Chicago, IL USA
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Kell, Alexander J. E.
Yamins, Daniel L. K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Psychol, Stanford, CA USA
Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA
Stanford Neurosci Inst, Stanford, CA USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Yamins, Daniel L. K.
Shook, Erica N.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Shook, Erica N.
Norman-Haignere, Sam V.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
Norman-Haignere, Sam V.
McDermott, Josh H.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
MIT, Ctr Brains Minds & Machines, 77 Massachusetts Ave, Cambridge, MA 02139 USA
Harvard Univ, Program Speech & Hearing Biosci & Technol, Cambridge, MA 02138 USAMIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA
机构:
Northeastern Univ, Boston, MA USA
Northeastern Univ, Dept Psychol, 675 ISEC,805 Columbus Ave, Boston, MA 02120 USANortheastern Univ, Boston, MA USA
Lloyd, Katherine M.
Morris, Timothy P.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Morris, Timothy P.
Anteraper, Sheeba
论文数: 0引用数: 0
h-index: 0
机构:
Carle Illinois Adv Imaging Ctr, Urbana, IL USANortheastern Univ, Boston, MA USA
Anteraper, Sheeba
论文数: 引用数:
h-index:
机构:
Voss, Michelle
Nieto-Castanon, Alfonso
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Nieto-Castanon, Alfonso
Whitfield-Gabrieli, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USANortheastern Univ, Boston, MA USA
Whitfield-Gabrieli, Susan
Fanning, Jason
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Univ, Winston Salem, NC USANortheastern Univ, Boston, MA USA
Fanning, Jason
Gothe, Neha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA
Gothe, Neha
Salerno, Elizabeth A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ St Louis, St Louis, MO USANortheastern Univ, Boston, MA USA
Salerno, Elizabeth A.
Erickson, Kirk I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Pittsburgh, PA USA
Univ Granada, PROFITH PROmoting FITness & Hlth Phys Act Res Grp, Granada, Spain
AdventHealth Res Inst, Neurosc Inst, Orlando, FL USANortheastern Univ, Boston, MA USA
Erickson, Kirk I.
Hillman, Charles H.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USA
Northeastern Univ, Dept Phys Therapy Movement & Rehabil Sci, Boston, MA USANortheastern Univ, Boston, MA USA
Hillman, Charles H.
Mcauley, Edward
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA
Mcauley, Edward
Kramer, Arthur F.
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Boston, MA USA
Univ Illinois, Urbana, IL USANortheastern Univ, Boston, MA USA