Sleep and Cognition in Children with Fetal Alcohol Spectrum Disorders (FASD) and Children with Autism Spectrum Disorders (ASD)

被引:22
作者
Mughal, Rabya [1 ]
Hill, Catherine M. [2 ]
Joyce, Anna [3 ]
Dimitriou, Dagmara [1 ]
机构
[1] UCL Inst Educ, Sleep Educ & Res Lab, Psychol & Human Dev, London WC1H 0AA, England
[2] Univ Southampton, Sch Clin & Expt Sci, Fac Med, Southampton SO16 6YD, Hants, England
[3] Regents Univ London, Sch Psychotherapy & Psychol, London NW1 4NS, England
基金
英国科研创新办公室;
关键词
sleep; fetal alcohol spectrum disorder; FASD; autism; autism spectrum disorder; ASD; actigraphy; cognition; REPETITIVE BEHAVIORS; ATTENTION; EXPOSURE; VALIDITY; ADOLESCENTS; RELIABILITY; SUBTYPES; DEFICIT; MEMORY; AGES;
D O I
10.3390/brainsci10110863
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Children with Fetal Alcohol Spectrum Disorders (FASD) and Autism Spectrum Disorders (ASD) experience significantly higher rates of sleep disturbances than their typically developing peers. However, little is known about the association between sleep and the cognitive phenotype in these clinical populations. Structural damage affecting cortical and subcortical connectivity occurs as a result of prenatal alcohol exposure in children with FASD, whilst it is believed an abundance of short-range connectivity explains the phenotypic manifestations of childhood ASD. These underlying neural structural and connectivity differences manifest as cognitive patterns, with some shared and some unique characteristics between FASD and ASD. This is the first study to examine sleep and its association with cognition in individuals with FASD, and to compare sleep in individuals with FASD and ASD. We assessed children aged 6-12 years with a diagnosis of FASD (n = 29), ASD (n = 21), and Typically Developing (TD) children (n = 46) using actigraphy (CamNTech Actiwatch 8), digit span tests of working memory (Weschler Intelligence Scale), tests of nonverbal mental age (MA; Ravens Standard Progressive Matrices), receptive vocabulary (British Picture Vocabulary Scale), and a choice reaction time (CRT) task. Children with FASD and ASD presented with significantly shorter total sleep duration, lower sleep efficiency, and more nocturnal wakings than their TD peers. Sleep was significantly associated with scores on the cognitive tests in all three groups. Our findings support the growing body of work asserting that sleep is significant to cognitive functioning in these neurodevelopmental conditions; however, more research is needed to determine cause and effect.
引用
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页码:1 / 20
页数:20
相关论文
共 64 条
[1]  
Abdel-Khalek AM, 2005, PERCEPT MOTOR SKILL, V101, P409, DOI 10.2466/pms.101.2.409-412
[2]   The Relationship between Sleep and Cognitive Performance in Autism Spectrum Disorder (ASD): A Pilot Study [J].
Al Backer, Nouf Backer ;
Alzawad, Malak ;
Habibullah, Hafiz ;
Bashir, Shahid .
CHILDREN-BASEL, 2018, 5 (11)
[3]  
Alloway T.P., 2012, WORKING MEMORY NEURO
[4]  
American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU, V5, DOI 10.1176/appi.books.9780890425596
[5]  
[Anonymous], 2012, OXFORD HDB SLEEP SLE
[6]  
[Anonymous], 2020, PSYCHT 3
[7]   Cross syndrome comparison of sleep problems in children with Down syndrome and Williams syndrome [J].
Ashworth, Anna ;
Hill, Catherine M. ;
Karmiloff-Smith, Annette ;
Dimitriou, Dagmara .
RESEARCH IN DEVELOPMENTAL DISABILITIES, 2013, 34 (05) :1572-1580
[8]  
Astley SJ, 2013, J POPUL THER CLIN PH, V20, pE416
[9]   Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders [J].
Astley, Susan J. ;
Aylward, Elizabeth H. ;
Olson, Heather Carmichael ;
Kerns, Kimberly ;
Brooks, Allison ;
Coggins, Truman E. ;
Davies, Julian ;
Dorn, Susan ;
Gendler, Beth ;
Jirikowic, Tracy ;
Kraegel, Paul ;
Maravilla, Kenneth ;
Richards, Todd .
JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 2009, 1 (01) :61-80
[10]   Working memory [J].
Baddeley, Alan .
CURRENT BIOLOGY, 2010, 20 (04) :R136-R140