Late-Onset Alzheimer Disease

被引：37
|
作者：
Pierce, Aimee L. [1 ,2 ]
Bullain, Szofia S. [3 ,4 ]
Kawas, Claudia H. [5 ,6 ,7 ,8 ]
机构：
[1] Univ Calif Irvine, Dept Neurol, 1100 Med Plaza Dr, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1100 Med Plaza Dr, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Neurol, 1515 Hewitt Hall, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1515 Hewitt Hall, Irvine, CA 92697 USA
[5] Univ Calif Irvine, Dept Neurol, 1121 Gillespie, Irvine, CA 92697 USA
[6] Univ Calif Irvine, Dept Neurobiol & Behav, 1121 Gillespie, Irvine, CA 92697 USA
[7] Univ Calif Irvine, Dept Epidemiol, 1121 Gillespie, Irvine, CA 92697 USA
[8] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1121 Gillespie, Irvine, CA 92697 USA
来源：
NEUROLOGIC CLINICS | 2017年 / 35卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Late-onset; Alzheimer disease; Dementia; Oldest-old; Pathology; OLDEST-OLD; DEMENTIA; ASSOCIATION; AGE; PREDICTORS; EFFICACY; COMMON; RISK;
D O I：
10.1016/j.ncl.2017.01.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.
引用
收藏
页码：283 / +
页数：13
相关论文
共 50 条
  • [21] Plasma Sphingomyelins in Late-Onset Alzheimer's Disease
    Fote, Gianna
    Wu, Jie
    Mapstone, Mark
    Macciardi, Fabio
    Fiandaca, Massimo S.
    Federoff, Howard J.
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 83 (03) : 1161 - 1171
  • [22] Neuropsychologic performance and depressed mood in sporadic late-onset Alzheimer disease
    Sánchez-Rodríguez, JL
    Rodríguez-Alvarez, M
    REVISTA DE NEUROLOGIA, 2004, 38 (07) : 625 - 630
  • [23] Glucose Metabolic Brain Networks in Early-Onset vs. Late-Onset Alzheimer's Disease
    Chung, Jinyong
    Yoo, Kwangsun
    Kim, Eunjoo
    Na, Duk L.
    Jeong, Yong
    FRONTIERS IN AGING NEUROSCIENCE, 2016, 8
  • [24] Evidence for an association between KIBRA and late-onset Alzheimer's disease
    Corneveaux, Jason J.
    Liang, Winnie S.
    Reiman, Eric M.
    Webster, Jennifer A.
    Myers, Amanda J.
    Zismann, Victoria L.
    Joshipura, Keta D.
    Pearson, John V.
    Hu-Lince, Diane
    Craig, David W.
    Coon, Keith D.
    Dunckley, Travis
    Bandy, Daniel
    Lee, Wendy
    Chen, Kewei
    Beach, Thomas G.
    Mastroeni, Diego
    Grover, Andrew
    Ravid, Rivka
    Sando, Sigrid B.
    Aasly, Jan O.
    Heun, Reinhard
    Jessen, Frank
    Koelsch, Heike
    Rogers, Joseph
    Hutton, Michael L.
    Melquist, Stacey
    Petersen, Ron C.
    Alexander, Gene E.
    Caselli, Richard J.
    Papassotiropoulos, Andreas
    Stephan, Dietrich A.
    Huentelman, Matthew J.
    NEUROBIOLOGY OF AGING, 2010, 31 (06) : 901 - 909
  • [25] Differences in Odor Identification in Early-Onset and Late-Onset Depression
    Liu, Meiling
    Chen, Ben
    Zhong, Xiaomei
    Zhang, Min
    Wang, Qiang
    Zhou, Huarong
    Wu, Zhangying
    Hou, Le
    Peng, Qi
    Zhang, Si
    Yang, Minfeng
    Lin, Gaohong
    Ning, Yuping
    BRAIN SCIENCES, 2022, 12 (02)
  • [26] Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease
    Aziz, Anne-Laure
    Giusiano, Bernard
    Joubert, Sven
    Duprat, Laureline
    Didic, Mira
    Gueriot, Claude
    Koric, Lejla
    Boucraut, Jose
    Felician, Olivier
    Ranjeva, Jean-Philippe
    Guedj, Eric
    Ceccaldi, Mathieu
    NEUROBIOLOGY OF AGING, 2017, 54 : 22 - 30
  • [27] Genetic profiles of familial late-onset Alzheimer's disease in China: The Shanghai FLOAD study
    Xie, Xin-Yi
    Zhao, Qian-Hua
    Huang, Qiang
    Dammer, Eric
    Chen, Sheng-di
    Ren, Ru-Jing
    Wang, Gang
    Alzheimer's Dis Neuroimaging Initiat
    GENES & DISEASES, 2022, 9 (06) : 1639 - 1649
  • [28] Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease
    Moller, Christiane
    Vrenken, Hugo
    Jiskoot, Lize
    Versteeg, Adriaan
    Barkhof, Frederik
    Scheltens, Philip
    van der Flier, Wiesje M.
    NEUROBIOLOGY OF AGING, 2013, 34 (08) : 2014 - 2022
  • [29] Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer's disease
    Gumus, Melisa
    Multani, Namita
    Mack, Michael L.
    Tartaglia, Maria Carmela
    GEROSCIENCE, 2021, 43 (01) : 213 - 223
  • [30] Brain aging and late-onset Alzheimer's disease: many open questions
    Behl, Christian
    INTERNATIONAL PSYCHOGERIATRICS, 2012, 24 : S3 - S9
12345