Copper-Mediated Phosphorylation of Arylsilanes with H-Phosphonate Diesters

Herein we report a facile method for the synthesis of arylphosphonates via copper-mediated the cross-coupling reaction in the presence of 1, 10-Phenanthroline and Ag2O. This method features a broad scope with respect to both the arylsilanes and H-phosphonate diesters. Mechanistically, the reaction is proposed to involve oxidation by phosphinyl radical and reductive elimination process as the two key steps. With the optimized conditions established, various arylphosphonates were obtained up to 74% yield. This protocol is the first example of copper mediated the Ar-P bond formation of various arylsilanes with H-phosphonates, and this novel methodology expands the applications of low cost and toxicity copper reagent in Ar-P bond construction.