A General and Convenient Catalytic Synthesis of Nitriles from Amides and Silanes

被引：130

作者：

Zhou, Shaolin ^{[1
]}

Junge, Kathrin ^{[1
]}

Addis, Daniele ^{[1
]}

Das, Shoubhik ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 11期

关键词：

BIOMIMETIC TRANSFER HYDROGENATION; IRON-PORPHYRIN CATALYSTS; ARYL HALIDES; PALLADIUM CATALYST; POTASSIUM HEXACYANOFERRATE(II); PHASE AMMOXIDATION; CARBONYL-COMPOUNDS; CYANATING AGENT; MILD SYNTHESIS; BROMIDES;

D O I：

10.1021/ol900716q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and convenient protocol for the catalytic dehydration of aromatic and aliphatic amides using silanes in the presence of catalytic amounts of fluoride is presented. The synthesis of aliphatic and aromatic nitrites proceeds with high selectivity under mild conditions. Notably, a wide substrate range is converted in good to excellent yields.

引用

页码：2461 / 2464

页数：4

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