Heart failure with preserved left ventricular ejection fraction

被引：0

作者：

Petutschnigg, Johannes ^{[1
,2
]}

Edelmann, Frank ^{[1
,2
,3
]}

机构：

[1] Charite Univ Med Berlin, Campus Virchow Klinikum, Med Klin Schwerpunkt Kardiol, Augustenburger Pl 1, D-13353 Berlin, Germany

[2] Deutsch Zentrum Herz Kreislauf Forsch DZHK, Standort Berlin, Berlin, Germany

[3] Charite Univ Med Berlin, Campus Virchow Klinikum, Berliner Inst Gesundheitsforsch, Berlin, Germany

来源：

INTERNIST | 2019年 / 60卷 / 09期

关键词：

Heart failure; diastolic; Dysfunction; Diagnostic; Therapy; Prognosis; REDUCE LAP-HF; DIASTOLIC DYSFUNCTION; EXERCISE CAPACITY; PHOSPHODIESTERASE-5; INHIBITION; CARDIAC RESYNCHRONIZATION; ALDOSTERONE ANTAGONISM; PULMONARY-HYPERTENSION; NATRIURETIC PEPTIDE; PHYSICAL-ACTIVITY; SYSTOLIC FUNCTION;

D O I：

10.1007/s00108-019-0653-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure remains the number one diagnosis among patients receiving inpatient treatment in Germany. Heart failure with preserved ejection fraction (HFpEF) needs to be verified by signs and symptoms of HF, echocardiographic parameters as well as cardiac biomarkers. Based on etiological and pathophysiological considerations, a classification into systolic and diastolic heart failure and later heart failure with reduced ejection fraction (HFrEF) and HFpEF was proposed. The inhomogeneous group of patients with HFpEF accounts for half of all heart failure cases in the population. Effective treatment options are limited. This article discusses which verified treatments may help or may even be harmful. A glimpse is taken into the future and those substances that are in advanced stages of clinical trials are described.

引用

页码：925 / 942

页数：18

共 72 条

[1] A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation [J].

Abraham, William T. ;

Kuck, Karl-Heinz ;

Goldsmith, Rochelle L. ;

Lindenfeld, JoAnn ;

Reddy, Vivek Y. ;

Carson, Peter E. ;

Mann, Douglas L. ;

Saville, Benjamin ;

Parise, Helen ;

Chan, Rodrigo ;

Wiegn, Phi ;

Hastings, Jeffrey L. ;

Kaplan, Andrew J. ;

Edelmann, Frank ;

Luthje, Lars ;

Kahwash, Rami ;

Tomassoni, Gery F. ;

Gutterman, David D. ;

Stagg, Angela ;

Burkhoff, Daniel ;

Hasenfuss, Gerd .

JACC-HEART FAILURE, 2018, 6 (10) :874-883

[2] Effects of digoxin on morbidity and mortality in diastolic heart failure: The ancillary Digitalis Investigation Group trial [J].

Ahmed, Ali ;

Rich, Michael W. ;

Fleg, Jerome L. ;

Zile, Michael R. ;

Young, James B. ;

Kitzman, Dalane W. ;

Love, Thomas E. ;

Aronow, Wilbert S. ;

Adams, Kirkwood F., Jr. ;

Gheorghiade, Mihai .

CIRCULATION, 2006, 114 (05) :397-403

[3]

American College of Cardiology, 2018, ANN SCI SESS

[4] Interaction Between Spironolactone and Natriuretic Peptides in Patients With Heart Failure and Preserved Ejection Fraction [J].

Anand, Inder S. ;

Claggett, Brian ;

Liu, Jiankang ;

Shah, Amil M. ;

Rector, Thomas S. ;

Shah, Sanjiv J. ;

Desai, Akshay S. ;

O'Meara, Eileen ;

Fleg, Jerome L. ;

Pfeffer, Marc A. ;

Pitt, Bertram ;

Solomon, Scott D. .

JACC-HEART FAILURE, 2017, 5 (04) :241-252

[5] Prognostic Value of Baseline Plasma Amino-Terminal Pro-Brain Natriuretic Peptide and Its Interactions With Irbesartan Treatment Effects in Patients With Heart Failure and Preserved Ejection Fraction Findings From the I-PRESERVE Trial [J].

Anand, Inder S. ;

Rector, Thomas S. ;

Cleland, John G. ;

Kuskowski, Michael ;

McKelvie, Robert S. ;

Persson, Hans ;

McMurray, John J. ;

Zile, Michael R. ;

Komajda, Michel ;

Massie, Barry M. ;

Carson, Peter E. .

CIRCULATION-HEART FAILURE, 2011, 4 (05) :569-577

[6] Heart Failure Stages Among Older Adults in the Community The Atherosclerosis Risk in Communities Study [J].

不详 .

CIRCULATION, 2017, 135 (03) :224-+

[7]

[Anonymous], 2017, NAT VERSORGUNGSLEITL

[8] Contractile behavior of the left ventricle in diastolic heart failure - With emphasis on regional systolic function [J].

Aurigemma, GP ;

Zile, MR ;

Gaasch, WH .

CIRCULATION, 2006, 113 (02) :296-304

[9] Role of atrial septostomy in the treatment of pulmonary vascular disease [J].

Barst, RJ .

THORAX, 2000, 55 (02) :95-96

[10] EJECTED FRACTION - AN INDEX OF MYOCARDIAL FUNCTION [J].

BARTLE, SH ;

SANMARCO, ME ;

DAMMANN, JF .

AMERICAN JOURNAL OF CARDIOLOGY, 1965, 15 (01) :125-&

← 1 2 3 4 5 6 7 8 →