Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children

被引：26

作者：

Ren, Xiaoya ^{[1
,2
,3
]}

Mou, Wenjun ^{[1
,3
]}

Su, Chang ^{[1
,2
]}

Chen, Xi ^{[1
,3
]}

Zhang, Hui ^{[1
,3
]}

Cao, Bingyan ^{[1
,2
]}

Li, Xiaoqiao ^{[1
,2
]}

Wu, Di ^{[1
,2
]}

Ni, Xin ^{[1
,4
]}

Gui, Jingang ^{[1
,3
]}

Gong, Chunxiu ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Minist Educ, Key Lab Major Dis Children, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Childrens Hosp, Dept Endocrinol Genet & Metab, Beijing 100045, Peoples R China

[3] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Immunol Lab, Beijing 100045, Peoples R China

[4] Capital Med Univ, Beijing Childrens Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100045, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2017年 / 13卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Children; Type 1 Diabetes Mellitus; Intermediate Monocytes; Islet Beta Cell Function; Memory T cells; CHRONIC KIDNEY-DISEASE; RHEUMATOID-ARTHRITIS; CD14(++)CD16(+) MONOCYTES; ACTIVATED MONOCYTES; TNF-ALPHA; T-CELLS; EXPRESSION; INFLAMMATION; MEMORY; MIGRATION;

D O I：

10.7150/ijbs.15659

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, and are therefore largely implicated in the development and progression of autoimmune diseases. The aim of this study was to analyze the change in the intermediate (CD14+ CD16+) monocyte subset in children with recent-onset type 1 diabetes mellitus (TIDM) and its possible association with clinical parameters reflecting islet beta-cell dysfunction. Compared with age-and sex-matched healthy controls, intermediate monocytes were expanded in children with TIDM, which was positively associated with hemoglobin A1C and negatively associated with serum insulin and C-peptide. Interestingly, the intermediate monocytes in TIDM patients expressed higher levels of human leukocyte antigen-DR and CD86, suggesting better antigen presentation capability. Further analysis revealed that the frequency of CD45RO+ CD4+ memory T cells was increased in the TIDM patients, and the memory T cell content was well correlated with the increase in intermediate monocytes. These results suggest that expanded intermediate monocytes are a predictive factor for the poor residual islet beta-cell function in children with recent-onset TIDM.

引用

页码：209 / 218

页数：10

共 50 条

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