Decoherence in yeast cell populations and its implications for genome-wide expression noise

被引:1
作者
Briones, M. R. S. [1 ]
Bosco, F. [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
来源
GENETICS AND MOLECULAR RESEARCH | 2009年 / 8卷 / 01期
基金
巴西圣保罗研究基金会;
关键词
Decoherence; Gene expression noise; Transcription; Cell biology; Biophysics; Mathematical biology; GENE-EXPRESSION;
D O I
10.4238/vol8-1gmr531
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gene expression "noise" is commonly defined as the stochastic variation of gene expression levels in different cells of the same population under identical growth conditions. Here, we tested whether this "noise" is amplified with time, as a consequence of decoherence in global gene expression profiles (genome-wide microarrays) of synchronized cells. The stochastic component of transcription causes fluctuations that tend to be amplified as time progresses, leading to a decay of correlations of expression profiles, in perfect analogy with elementary relaxation processes. Measuring decoherence, defined here as a decay in the auto-correlation function of yeast genome-wide expression profiles, we found a slowdown in the decay of correlations, opposite to what would be expected if, as in mixing systems, correlations decay exponentially as the equilibrium state is reached. Our results indicate that the populational variation in gene expression (noise) is a consequence of temporal decoherence, in which the slow decay of correlations is a signature of strong interdependence of the transcription dynamics of different genes.
引用
收藏
页码:47 / 51
页数:5
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