The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

被引：24

作者：

Lin, Shih-Yi ^{[1
,2
,3
]}

Lin, Wei-Ming ^{[4
,5
]}

Lin, Cheng-Li ^{[6
,7
]}

Yang, Tse-Yen ^{[8
]}

Sung, Fung-Chang ^{[6
,7
]}

Wang, Yuan-Hung ^{[9
,10
]}

Kao, Chia-Hung ^{[1
,11
,12
,13
]}

机构：

[1] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung 404, Taiwan

[2] China Med Univ Hosp, Div Nephrol, Taichung, Taiwan

[3] China Med Univ Hosp, Kidney Inst, Taichung, Taiwan

[4] Chang Gung Mem Hosp, Dept Diagnost Radiol, Chiayi, Taiwan

[5] Chang Gung Univ, Tao Yuan, Taiwan

[6] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[7] China Med Univ, Coll Med, Dept Publ Hlth, Taichung 404, Taiwan

[8] China Med Univ, China Med Univ Hosp, Mol & Genom Epidemiol Ctr, Taichung 404, Taiwan

[9] Taipei Med Univ, Shuang Ho Hosp, Dept Surg, Div Urol, New Taipei City, Taiwan

[10] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan

[11] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[12] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

[13] China Med Univ, Coll Med, Sch Med, Taichung 404, Taiwan

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2014年 / 25卷 / 03期

关键词：

End-stage renal disease; Hyperparathyroidism; Thyroid cancer; CHRONIC DIALYSIS PATIENTS; PARATHYROIDECTOMY; ASSOCIATION; DYSFUNCTION; MALIGNANCY; RISK;

D O I：

10.1016/j.ejim.2014.01.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods: This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results: We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion: These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT. (C) 2014 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved.

引用

页码：276 / 280

页数：5

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