Electrostatically Tuned Self-Assembly of Branched Amphiphilic Peptides

被引：4

作者：

Ting, Christina L. ^{[1
]}

Frischknecht, Amalie L. ^{[1
,2
]}

Stevens, Mark J. ^{[1
,2
]}

Spoerke, Erik D. ^{[1
]}

机构：

[1] Sandia Natl Labs, Albuquerque, NM 87185 USA

[2] Sandia Natl Labs, Ctr Integrated Nanotechnol, Albuquerque, NM 87185 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2014年 / 118卷 / 29期

关键词：

PROTEIN; NANOSTRUCTURES; COPOLYMERS; NANOTUBES; MICELLES; POLYMER;

D O I：

10.1021/jp503414p

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Electrostatics plays an important role in the self-assembly of amphiphilic peptides. To develop a molecular understanding of the role of the electrostatic interactions, we develop a coarse-grained model peptide and apply self-consistent field theory to investigate the peptide assembly into a variety of aggregate nanostructures. We find that the presence and distribution of charged groups on the hydrophilic branches of the peptide can modify the molecular configuration from extended to collapsed. This change in molecular configuration influences the packing into spherical micelles, cylindrical micelles (nanofibers), or planar bilayers. The effects of charge distribution therefore have important implications for the design and utility of functional materials based on peptides.

引用

页码：8624 / 8630

页数：7

共 35 条

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