BPI-23314: A novel orally bioavailable small molecular BET inhibitor with target protein degradation activity

被引:0
|
作者
Guo, Jing [1 ]
Xu, Yan [1 ]
Yan, Dan [1 ]
Yu, Bo [1 ]
Yu, Weiwei [1 ]
Chen, Haibo [1 ]
Xu, Xiaofeng [1 ]
Liu, Xiangyong [1 ]
Lan, Hong [1 ]
Ding, Lieming [1 ]
Wang, Jiabing [1 ]
机构
[1] Betta Pharmaceut Co LTD, Hangzhou, Peoples R China
关键词
D O I
10.1158/1538-7445.AM2020-1751
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1751
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Phase 1 study of BPI-23314, a novel BET inhibitor and degrader, in advanced myeloid leukemia (AML)
    Sun, Mingyuan
    Jin, Xiangyu
    Guo, Jing
    Liu, Xiaoyun
    Xu, Yan
    Lan, Hong
    Wang, Jiabing
    Zhen, Jiangnan
    Yang, Jing
    Ding, Lieming
    Qi, Junyuan
    CANCER RESEARCH, 2024, 84 (07)
  • [2] BPI-371153, an orally bioavailable small molecule PD-L1 inhibitor
    Wang, Yiqian
    Jing, Xiangyan
    Chen, Hong
    Zhang, Huijuan
    Ma, Tianyi
    Zhang, Yao
    Zhang, Chunhui
    Zhang, Guangzhi
    Liu, Xiangyong
    Yan, Dan
    Guo, Jing
    Lan, Hong
    Wang, Jiabing
    Ding, Lieming
    CANCER RESEARCH, 2022, 82 (12)
  • [3] BPI-472372: a potent and orally bioavailable small molecule inhibitor of CD73 for cancer immunotherapy
    Han, Han
    Yang, Xiaofeng
    Zhao, Ying
    Wang, Jin
    Yang, Xiang
    Ju, Xuepeng
    Zhao, Jiayu
    Zou, Zhengyao
    Chen, Haibo
    Liu, Xiaoyun
    Guo, Jing
    Yang, Cheng
    Lan, Hong
    Wu, Hao
    Ding, Lieming
    Wang, Jiabing
    CANCER RESEARCH, 2023, 83 (07)
  • [4] A novel orally bioavailable small molecular ENPP1 inhibitor (OC-1) for cancer immunotherapy
    Chen, Jiyun
    Pujala, Brahmam
    Gupta, Ashu
    Ansaria, Amantullah
    Khana, Farha
    Lee, Elbert
    Chakravarty, Sarvajit
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [5] Preclinical Characterization of TTI-281, a Novel, Orally Bioavailable BET Inhibitor: Predictive Biomarker Identification and Combination Treatment Analysis
    Choi, Jaehyun
    Wang, Chunlei
    Wang, Zezhou
    Schimmer, Aaron D.
    Petrova, Penka S.
    Slassi, Malik
    Uger, Robert A.
    BLOOD, 2016, 128 (22)
  • [6] Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
    Sperandio, David
    Aktoudianakis, Vangelis
    Babaoglu, Kerim
    Chen, Xiaowu
    Elbel, Kristyna
    Chin, Gregory
    Corkey, Britton
    Du, Jinfa
    Jiang, Bob
    Kobayashi, Tetsuya
    Mackman, Richard
    Martinez, Ruben
    Yang, Hai
    Zablocki, Jeff
    Kusam, Saritha
    Jordan, Kim
    Webb, Heather
    Bates, Jamie G.
    Lad, Latesh
    Mish, Michael
    Niedziela-Majka, Anita
    Metobo, Sammy
    Sapre, Annapurna
    Hung, Magdeleine
    Jin, Debi
    Fung, Wanchi
    Kan, Elaine
    Eisenberg, Gene
    Larson, Nate
    Newby, Zachary E. R.
    Lansdon, Eric
    Tay, Chin
    Neve, Richard M.
    Shevick, Sophia L.
    Breckenridge, David G.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (03) : 457 - 469
  • [7] Discovery of RG7834 and target identification: First-in-class selective and orally bioavailable small molecule HBV expression inhibitor with a novel mechanism of action
    Yang, Song
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [8] Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1
    Meropi Bagka
    Hyeonyi Choi
    Margaux Héritier
    Hanna Schwaemmle
    Quentin T. L. Pasquer
    Simon M. G. Braun
    Leonardo Scapozza
    Yibo Wu
    Sascha Hoogendoorn
    Nature Communications, 14
  • [9] Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1
    Bagka, Meropi
    Choi, Hyeonyi
    Heritier, Margaux
    Schwaemmle, Hanna
    Pasquer, Quentin T. L.
    Braun, Simon M. G.
    Scapozza, Leonardo
    Wu, Yibo
    Hoogendoorn, Sascha
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [10] Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction
    Wang, Zhen
    Zhang, Min
    Quereda, Victor
    Frydman, Sylvia M.
    Ming, Qianqian
    Luca, Vincent C.
    Duckett, Derek R.
    Ji, Haitao
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (16) : 12109 - 12131