Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers

被引:31
作者
Ferguson, J. F. [1 ]
Ryan, M. F. [2 ]
Gibney, E. R. [2 ]
Brennan, L. [2 ]
Roche, H. M. [2 ,3 ]
Reilly, M. P. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA
[2] Univ Coll Dublin, UCD Inst Food & Hlth, Dublin, Ireland
[3] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, Conway Inst, Dublin, Ireland
关键词
Cardiometabolic disease; Endotoxemia; LPS; Isoflavone; Soy; Inflammation; Insulin sensitivity; HIGH-FAT DIET; CARDIOVASCULAR-DISEASE; SOY; GENISTEIN; CANCER; ENDOTOXEMIA; CELLS; MODEL;
D O I
10.1016/j.numecd.2014.03.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aims: Consumption of foods that modulate inflammatory stress in genetically-prone individuals may influence development of cardiometabolic diseases. Isoflavones in soy-derived foods function as phytoestrogens, have antioxidant and antiinflammatory activity, inhibit protein-tyrosine kinase activity, and may be atheroprotective. We examined the relationship between soy food consumption and inflammatory responses to endotoxemia, postprandial responses to oral lipid tolerance test (OLTT), and insulin sensitivity from frequently sampled intravenous tolerance tests (FSIGTT). Methods and results: We administered low-dose endotoxin (LPS 1 ng/kg) to induce transient endotoxemia in young, healthy volunteers (N = 215) of African (AA), and European (EA) ancestry as part of the GENE Study. We further supported these findings in two independent samples: the MECHE Study and NHANES. Soy food consumption was a significant predictor of peak cytokine response following LPS. Individuals with moderate-high (>1.48 mg/day, N = 65) vs. low-no (<1.48 mg/day, N = 150) isoflavone consumption had significantly higher tumor necrosis factor alpha (TNF alpha) post-LPS (AUC, P = 0.009). Further, high-isoflavone consumers were protected against inflammation-induced decline in insulin sensitivity (SI) in GENE. We observed significant differences by soy consumption in the interferon gamma (IFN gamma) response to OLTT, and the insulin response to OGTT in MECHE, as well as significantly lower fasting insulin, and 2-hour glucose post-OGTT in EA NHANES subjects. Conclusion: We demonstrate that soy consumption may influence inflammatory and metabolic responses. In research of nutritional exposures, measuring evoked phenotypes may be more informative than describing resting characteristics. The GENE Study was registered under NCT00953667 and the MECHE Study under NCT01172951, both at clinicaltrials.gov. (C) 2014 Elsevier B. V. All rights reserved.
引用
收藏
页码:996 / 1003
页数:8
相关论文
共 35 条
  • [1] AKIYAMA T, 1987, J BIOL CHEM, V262, P5592
  • [2] Recent advances in understanding the anti-diabetic actions of dietary flavonoids
    Babu, Pon Velayutham Anandh
    Liu, Dongmin
    Gilbert, Elizabeth R.
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (11) : 1777 - 1789
  • [3] Predicting Diabetes: Clinical, Biological, and Genetic Approaches Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Balkau, Beverley
    Lange, Celine
    Fezeu, Leopold
    Tichet, Jean
    De Lauzon-Guillain, Blandine
    Cernichow, Sebastien
    Fumeron, Frederic
    Froguel, Philippe
    Vaxillaire, Martine
    Cauchi, Stephane
    Ducimetiere, Pierre
    Eschwege, Eveline
    [J]. DIABETES CARE, 2008, 31 (10) : 2056 - 2061
  • [4] Nutritional methods in the European prospective investigation of cancer in Norfolk
    Bingham, SA
    Welch, AA
    McTaggart, A
    Mulligan, AA
    Runswick, SA
    Luben, R
    Oakes, S
    Khaw, KT
    Wareham, N
    Day, NE
    [J]. PUBLIC HEALTH NUTRITION, 2001, 4 (03) : 847 - 858
  • [5] Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
    Boroni Moreira, Ana Paula
    Salles Texeira, Tatiana Fiche
    Ferreira, Alessandra Barbosa
    Gouveia Peluzio, Maria do Carmo
    Goncalves Alfenas, Rita de Cassia
    [J]. BRITISH JOURNAL OF NUTRITION, 2012, 108 (05) : 801 - 809
  • [6] Boston Ray C, 2003, Diabetes Technol Ther, V5, P1003, DOI 10.1089/152091503322641060
  • [7] Dietary factors and low-grade inflammation in relation to overweight and obesity
    Calder, Philip C.
    Ahluwalia, Namanjeet
    Brouns, Fred
    Buetler, Timo
    Clement, Karine
    Cunningham, Karen
    Esposito, Katherine
    Jonsson, Lena S.
    Kolb, Hubert
    Lansink, Mirian
    Marcos, Ascension
    Margioris, Andrew
    Matusheski, Nathan
    Nordmann, Herve
    O'Brien, John
    Pugliese, Giuseppe
    Rizkalla, Salwa
    Schalkwijk, Casper
    Tuomilehto, Jaakko
    Waernberg, Julia
    Watzl, Bernhard
    Winklhofer-Roob, Brigitte M.
    [J]. BRITISH JOURNAL OF NUTRITION, 2011, 106 : S1 - S78
  • [8] Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
    Chen, Rui
    Mias, George I.
    Li-Pook-Than, Jennifer
    Jiang, Lihua
    Lam, Hugo Y. K.
    Chen, Rong
    Miriami, Elana
    Karczewski, Konrad J.
    Hariharan, Manoj
    Dewey, Frederick E.
    Cheng, Yong
    Clark, Michael J.
    Im, Hogune
    Habegger, Lukas
    Balasubramanian, Suganthi
    O'Huallachain, Maeve
    Dudley, Joel T.
    Hillenmeyer, Sara
    Haraksingh, Rajini
    Sharon, Donald
    Euskirchen, Ghia
    Lacroute, Phil
    Bettinger, Keith
    Boyle, Alan P.
    Kasowski, Maya
    Grubert, Fabian
    Seki, Scott
    Garcia, Marco
    Whirl-Carrillo, Michelle
    Gallardo, Mercedes
    Blasco, Maria A.
    Greenberg, Peter L.
    Snyder, Phyllis
    Klein, Teri E.
    Altman, Russ B.
    Butte, Atul J.
    Ashley, Euan A.
    Gerstein, Mark
    Nadeau, Kari C.
    Tang, Hua
    Snyder, Michael
    [J]. CELL, 2012, 148 (06) : 1293 - 1307
  • [9] Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice
    Cheong, Sun Hee
    Furuhashi, Keisuke
    Ito, Katsuki
    Nagaoka, Masato
    Yonezawa, Takayuki
    Miura, Yutaka
    Yagasaki, Kazumi
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2014, 25 (02) : 136 - 143
  • [10] Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers
    Ferguson, Jane F.
    Mulvey, Claire K.
    Patel, Parth N.
    Shah, Rhia Y.
    Doveikis, Julia
    Zhang, Weiyu
    Tabita-Martinez, Jennifer
    Terembula, Karen
    Eiden, Michael
    Koulman, Albert
    Griffin, Julian L.
    Mehta, Nehal N.
    Shah, Rachana
    Propert, Kathleen J.
    Song, Wen-Liang
    Reilly, Muredach P.
    [J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2014, 58 (03) : 601 - 613