Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

被引：13
作者：
Szczepankiewicz, Aleksandra [1 ]
Rose-Zerilli, Matthew J. [2 ,3 ]
Barton, Sheila J. [3 ]
Holgate, Stephen T. [3 ]
Holloway, John W. [2 ,3 ]
机构：
[1] Karol Marcinkowski Univ Med Sci, Dept Pediat 3, Dept Pediat Pneumonol Allergy & Clin Immunol, PL-60572 Poznan, Poland
[2] Univ Southampton, Sch Med, Div Human Genet, Southampton, Hants, England
[3] Univ Southampton, Sch Med, Div Infect Inflammat & Repair, Southampton, Hants, England
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2009年 / 149卷 / 04期
关键词：
Asthma; Brain-derived neurotrophic factor; Polymorphism; BDNF; NERVE GROWTH-FACTOR; BIPOLAR DISORDER; BDNF-GENE; CONFERS SUSCEPTIBILITY; AIRWAY INFLAMMATION; ALLERGIC ASTHMATICS; ALZHEIMERS-DISEASE; MOUSE MODEL; SCHIZOPHRENIA; ACTIVATION;
D O I：
10.1159/000205580
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Background: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. Methods: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442). Results: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV1 % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores. Conclusions: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：343 / 349
页数：7
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