The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

被引：363
|
作者：
Christofides, Anthos [1 ,2 ,3 ]
Konstantinidou, Eirini [1 ,2 ,3 ]
Jani, Chinmay [2 ,4 ]
Boussiotis, Vassiliki A. [1 ,2 ,3 ]
机构：
[1] Harvard Med Sch, Div Hematol Oncol, Boston, MA 02215 USA
[2] Harvard Med Sch, Dept Med, Boston, MA 02215 USA
[3] Harvard Med Sch, Ctr Canc, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[4] Mt Auburn Hosp, Dept Med, Cambridge, MA 02138 USA
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 114卷
基金：
美国国家卫生研究院;
关键词：
PPAR; Metabolism; Inflammation; T cells; Myeloid cells; FATTY-ACID OXIDATION; REGULATE MACROPHAGE POLARIZATION; FOAM-CELL-FORMATION; RAT ADIPOSE-TISSUE; DELTA AGONIST; GENE-EXPRESSION; T-CELLS; MESSENGER-RNA; BETA/DELTA ACTIVATION; TRANSCRIPTION FACTOR;
D O I：
10.1016/j.metabol.2020.154338
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPAR alpha, PPAR gamma, and PPAR beta/6. PPAR alpha and PPAR6 are highly expressed in oxidative tissues and regulate genes involved in substrate delivery and oxidative phosphorylation (OXPHOS) and regulation of energy homeostasis. In contrast, PPAR gamma is more important in lipogenesis and lipid synthesis, with highest expression levels in white adipose tissue (WAT). In addition to tissues regulating whole body energy homeostasis, PPARs are expressed in immune cells and have an emerging critical role in immune cell differentiation and fate commitment. In this review, we discuss the actions of PPARs in the function of the innate and the adaptive immune system and their implications in immune-mediated inflammatory conditions. (C) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页数：13
相关论文
共 50 条
  • [31] Role of the fatty acids in ovarian functions: Involvement of Peroxisome Proliferator-Activated Receptors (PPAR) and adipokines
    Dupont, J.
    Froment, P.
    Rame, C.
    Pierre, P.
    Coyral-Castel, S.
    Chabrolle, C.
    GYNECOLOGIE OBSTETRIQUE & FERTILITE, 2008, 36 (12): : 1230 - 1238
  • [32] Proliferating peroxisome proliferator-activated receptors
    不详
    DIABETES OBESITY & METABOLISM, 2000, 2 (05): : 332 - 333
  • [33] Peroxisome proliferator-activated receptors and inflammation
    Moraes, Leonardo A.
    Piqueras, Laura
    Bishop-Bailey, David
    PHARMACOLOGY & THERAPEUTICS, 2006, 110 (03) : 371 - 385
  • [34] Peroxisome proliferator-activated receptors and their functions
    Jiao, HL
    Ye, P
    Zhao, BL
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2001, 28 (04) : 478 - 481
  • [35] Peroxisome proliferator-activated receptors for hypertension
    Usuda, Daisuke
    Kanda, Tsugiyasu
    WORLD JOURNAL OF CARDIOLOGY, 2014, 6 (08): : 744 - 754
  • [36] Peroxisome proliferator-activated receptors.
    Ziouzenkova O.
    Perrey S.
    Marx N.
    Bacqueville D.
    Plutzky J.
    Current Atherosclerosis Reports, 2002, 4 (1) : 59 - 64
  • [37] Peroxisome Proliferator-Activated Receptors and Atherosclerosis
    Soskic, Sanja S.
    Dobutovic, Branislava D.
    Sudar, Emina M.
    Obradovic, Milan M.
    Nikolic, Dragana M.
    Zaric, Bozidarka L.
    Stojanovic, Srdan D.
    Stokic, Edita J.
    Mikhailidis, Dimitri P.
    Isenovic, Esma R.
    ANGIOLOGY, 2011, 62 (07) : 523 - 534
  • [38] Signalling by peroxisome proliferator-activated receptors
    Wahli, W
    Krey, G
    Devchand, P
    Keller, H
    Ijpenberg, A
    Jeannin, E
    Braissant, O
    Desvergne, A
    BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 : U79 - U79
  • [39] Peroxisome proliferator-activated receptors and angiogenesis
    Biscetti, F.
    Straface, G.
    Pitocco, D.
    Zaccardi, F.
    Ghirlanda, G.
    Flex, A.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2009, 19 (11) : 751 - 759
  • [40] Regulation of peroxisome proliferator-activated receptors
    Sorensen, HN
    Treuter, E
    Gustafsson, JA
    VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 54, 1998, 54 : 121 - 166
12345