Sense Ginsenosides From Ginsengs: Structure-Activity Relationship in Autophagy

被引：8
作者：
Wu, Tao [1 ]
Kwaku, Osafo Raymond [1 ]
Li, Hai-Zhou [1 ]
Yang, Chong-Ren [2 ]
Ge, Long-Jiao [3 ]
Xu, Min [1 ]
机构：
[1] Kunming Univ Sci & Technol, Ctr Pharmaceut Sci, Fac Life Sci & Technol, Chenggong Campus, Kunming 650500, Yunnan, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Zool, Translat Lab Primate Brain Res, Kunming 650201, Yunnan, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 06期
关键词：
ginsengs; ginsenosides; structure-activity relationship; autophagy; DAMMARANE-TYPE SAPONINS; PANAX-NOTOGINSENG; HEPATOCELLULAR-CARCINOMA; GYPENOSIDE XVII; STEAMED ROOTS; CANCER CELLS; PC12; CELLS; RG1; APOPTOSIS; INHIBITION;
D O I：
10.1177/1934578X19858223
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The term ginseng refers to the dried roots of several plants belonging to the genus Panax of the Araliaceae family. The 3 major commercial ginsengs are Panax notoginseng (Burk.) F.H. Chen (Notoginseng), P. ginseng C.A. Meyer (Ginseng), and P. quinquefolius L. (American ginseng), which have been used as herbal medicines. Over 18,000 papers on ginsengs have been published on the basis of their structural diversity and biological activities. Many reviews have summarized the phytochemistry, pharmacology, and clinical use of ginsengs, but the structure-activity relationship (SAR) of ginsenosides from ginsengs in autophagy is unavailable. Herein, we review the structural diversity of ginsenosides, especially the ones in notoginseng, and the SAR in autophagic activity is discussed in detail.
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页数：10
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