Sense Ginsenosides From Ginsengs: Structure-Activity Relationship in Autophagy

被引：8

作者：

Wu, Tao ^{[1
]}

Kwaku, Osafo Raymond ^{[1
]}

Li, Hai-Zhou ^{[1
]}

Yang, Chong-Ren ^{[2
]}

Ge, Long-Jiao ^{[3
]}

Xu, Min ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Ctr Pharmaceut Sci, Fac Life Sci & Technol, Chenggong Campus, Kunming 650500, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Translat Lab Primate Brain Res, Kunming 650201, Yunnan, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 06期

关键词：

ginsengs; ginsenosides; structure-activity relationship; autophagy; DAMMARANE-TYPE SAPONINS; PANAX-NOTOGINSENG; HEPATOCELLULAR-CARCINOMA; GYPENOSIDE XVII; STEAMED ROOTS; CANCER CELLS; PC12; CELLS; RG1; APOPTOSIS; INHIBITION;

D O I：

10.1177/1934578X19858223

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The term ginseng refers to the dried roots of several plants belonging to the genus Panax of the Araliaceae family. The 3 major commercial ginsengs are Panax notoginseng (Burk.) F.H. Chen (Notoginseng), P. ginseng C.A. Meyer (Ginseng), and P. quinquefolius L. (American ginseng), which have been used as herbal medicines. Over 18,000 papers on ginsengs have been published on the basis of their structural diversity and biological activities. Many reviews have summarized the phytochemistry, pharmacology, and clinical use of ginsengs, but the structure-activity relationship (SAR) of ginsenosides from ginsengs in autophagy is unavailable. Herein, we review the structural diversity of ginsenosides, especially the ones in notoginseng, and the SAR in autophagic activity is discussed in detail.

引用

页数：10

共 75 条

[1] Antiaging Therapy: A Novel Target for Antilipolytic Drugs [J].

Cavallini, Gabriella ;

Donati, Alessio ;

Bergamini, Ettore .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2014, 14 (07) :551-556

[2] Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation [J].

Chen, Lei ;

Meng, Yue ;

Sun, Qi ;

Zhang, Zhongyu ;

Guo, Xiaoqing ;

Sheng, Xiaotong ;

Tai, Guihua ;

Cheng, Hairong ;

Zhou, Yifa .

CELL DEATH & DISEASE, 2016, 7 :e2334-e2334

[3] Stereoisomer-Specific Anticancer Activities of Ginsenoside Rg3 and Rh2 in HepG2 Cells: Disparity in Cytotoxicity and Autophagy-Inducing Effects Due to 20(S)-Epimers [J].

Cheong, Jong Hye ;

Kim, Hyeryung ;

Hong, Min Jee ;

Yang, Min Hye ;

Kim, Jung Wha ;

Yoo, Hunseung ;

Yang, Heejung ;

Park, Jeong Hill ;

Sung, Sang Hyun ;

Kim, Hong Pyo ;

Kim, Jinwoong .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, 38 (01) :102-108

[4]

Cho SK, 2015, AUTOPHAGY: CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY, INFECTION, AND AGING, VOL 5: ROLE IN HUMAN DISEASES, P81, DOI 10.1016/B978-0-12-801033-4.00004-7

[5] Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1 [J].

Choi, Pilju ;

Park, Jun Yeon ;

Kim, Taejung ;

Park, Soon-Hye ;

Kim, Ho-Kyong ;

Kang, Ki Sung ;

Ham, Jungyeoh .

JOURNAL OF FUNCTIONAL FOODS, 2015, 14 :613-622

[6] Autophagy: a new pathway for traditional Chinese medicine [J].

Cui, Bing ;

Yu, Jin-Mei .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2018, 20 (01) :14-26

[7] Analysis methods of ginsenosides [J].

Fuzzati, N .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 812 (1-2) :119-133

[8] New triterpenoid saponins from the steaming treated roots of Panax notoginseng [J].

Gu, Cheng-Zhen ;

Qiao, Yi-Jun ;

Wang, Dong ;

Zhu, Hong-Tao ;

Yang, Chong-Ren ;

Xu, Min ;

Zhang, Ying-Jun .

NATURAL PRODUCT RESEARCH, 2018, 32 (03) :294-301

[9] Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng [J].

Gu, Cheng-Zhen ;

Lv, Jun-Jiang ;

Zhang, Xiao-Xia ;

Qiao, Yi-Jun ;

Yan, Hui ;

Li, Yan ;

Wang, Dong ;

Zh, Hong-Tao ;

Luo, Huai-Rong ;

Yang, Chong-Ren ;

Xu, Min ;

Zhang, Ying-Jun .

JOURNAL OF NATURAL PRODUCTS, 2015, 78 (08) :1829-1840

[10] Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng [J].

Gu, Cheng-Zhen ;

Lv, Jun-Jiang ;

Zhang, Xiao-Xia ;

Yan, Hui ;

Zhu, Hong-Tao ;

Luo, Huai-Rong ;

Wang, Dong ;

Yang, Chong-Ren ;

Xu, Min ;

Zhang, Ying-Jun .

FITOTERAPIA, 2015, 103 :97-105

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