Clinical experience of IL-6 blockade in rheumatic diseases-Implications on IL-6 biology and disease pathogenesis

被引：32
作者：
Davies, Ruth [1 ]
Choy, Ernest [1 ]
机构：
[1] Cardiff Univ, Rheumatol Sect, Inst Infect & Immun, CREATE Ctr, Cardiff CF14 4XN, S Glam, Wales
来源：
SEMINARS IN IMMUNOLOGY | 2014年 / 26卷 / 01期
关键词：
Interleukin-6; Rheumatology; IL-6; blockade; Pathogenesis; INTERLEUKIN-6 RECEPTOR BLOCKADE; JUVENILE IDIOPATHIC ARTHRITIS; NECROSIS-FACTOR-ALPHA; TOCILIZUMAB TREATMENT; SERUM INTERLEUKIN-6; SUSTAINED RESPONSE; DOUBLE-BLIND; T-CELLS; LUPUS; INHIBITION;
D O I：
10.1016/j.smim.2013.12.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin 6 (IL-6) plays a significant role in many rheumatological diseases and has been described as both a pro- and anti-inflammatory cytokine. IL-6 blockade has been investigated in various rheumatic diseases and a humanised anti-IL-6 receptor antibody has been licensed for use in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis. The increasing clinical experience of IL-6 blockade in rheumatic diseases adds to the existing knowledge regarding the physiological and pathological roles of IL-6. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：97 / 104
页数：8
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