One-step method for synthesis of 2,4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn(OTf)2 as the catalyst

被引：8

作者：

Madabhushi, Sridhar ^{[1
]}

Mallu, Kishore Kumar Reddy ^{[1
]}

Jillella, Raveendra ^{[1
]}

Kurva, Srinivas ^{[1
]}

Singh, Rajpal ^{[2
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500607, Andhra Pradesh, India

[2] DRDO, Ctr Fire Explos & Environm Safety, New Delhi 110054, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 12期

关键词：

2-Aminoaryl ketone; Hydroxamic acid; Quinazoline; 3-oxides; Zinc(II) triflate; Lewis acid catalysis; RING ENLARGEMENT; 1,4-BENZODIAZEPINES; DERIVATIVES; EXPANSION; AGENTS;

D O I：

10.1016/j.tetlet.2014.01.150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for the preparation of 2,4-disubstituted quinazoline 3-oxides by reaction of a hydroxamic acid with 2-aminoaryl ketones using zinc(II) triflate as the catalyst is described. (c) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1979 / 1982

页数：4

共 28 条

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