New Efficient Synthesis of 5-Ethoxyoxazoles and Oxazolo[3,2-c]quinazolines via Aza-Wittig Reaction

被引：19

作者：

Huang, Nian-Yu ^{[1
]}

Nie, Yi-Bo ^{[1
]}

Ding, Ming-Wu ^{[1
]}

机构：

[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China

来源：

SYNLETT | 2009年 / 04期

基金：

中国国家自然科学基金;

关键词：

oxazole; oxazolo[3,2-c]quinazoline; aza Wittig reaction; carbodiimide; imidoyl chloride; IMINOPHOSPHORANE-MEDIATED SYNTHESIS; FACILE SYNTHESIS; OXAZOLES; ROUTE;

D O I：

10.1055/s-0028-1087562

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Ethoxyoxazoles or 2-acylamino propanoates were synthesized by aza-Wittig reaction of iminophosphorane with acyl chloride in the presence of triethylamine. Reactions of 5-alkoxyoxazole with triphenyphosphine produced iminophosphoranes. A tandem aza-Wittig reaction of iminophosphorane with isocyanate or carbon disulfide generated oxazolo[3,2-c]quinazolines in satisfactory yields.

引用

页码：611 / 614

页数：4

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