Biopolymeric alginate-chitosan nanoparticles as drug delivery carriers for cancer therapy

被引：48
作者：
Bhunchu, S. [1 ]
Rojsitthisak, P. [2 ]
机构：
[1] Chulalongkorn Univ, PhD Program Nanosci & Technol Int, Grad Sch, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Met & Mat Sci Res Inst, Bangkok 10330, Thailand
来源：
PHARMAZIE | 2014年 / 69卷 / 08期
关键词：
IN-VITRO CHARACTERIZATION; NEUTRON-CAPTURE THERAPY; TURMERIC OIL; ALGINATE/CHITOSAN NANOPARTICLES; TARGETED DELIVERY; OCULAR DELIVERY; ANTICANCER DRUG; NANOCAPSULES; MICROPARTICLES; ENCAPSULATION;
D O I：
10.1691/ph.2014.3165
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nanoparticulate drug delivery systems enhance cancer treatment by direct entry of nanometer particles into the fenestration in the vasculature of cancer cells. Nanoparticles for encapsulation of anticancer drugs are preferably prepared using natural polymers as carriers, with polysaccharides being particularly favorable. Alginate and chitosan polysaccharides have been widely used in nanoparticulate drug delivery systems because of their biodegradable, biocompatible, non-toxic and bioadhesive properties. In this review, we present an overview Of drug delivery systems for cancer treatment, describe the use of biopolymeric alginate-chitosan nanoparticles for anticancer drug delivery, and discuss the important characteristics of these nanoparticles for use in drug delivery.
引用
收藏
页码：563 / 570
页数：8
相关论文
共 61 条
[1]   Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].
Agnihotri, SA ;
Mallikarjuna, NN ;
Aminabhavi, TM .
JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :5-28
[2]   Cancer is a Preventable Disease that Requires Major Lifestyle Changes [J].
Anand, Preetha ;
Kunnumakara, Ajaikumar B. ;
Sundaram, Chitra ;
Harikumar, Kuzhuvelil B. ;
Tharakan, Sheeja T. ;
Lai, Oiki S. ;
Sung, Bokyung ;
Aggarwal, Bharat B. .
PHARMACEUTICAL RESEARCH, 2008, 25 (09) :2097-2116
[3]  
[Anonymous], 2008, Nanotechnol.L. Bus
[4]  
[Anonymous], 2011, Cancer Facts and Figures 2011
[5]  
[Anonymous], 2011, Int. j. appl. Biol Pharm Tech
[6]   Therapeutic potential of nanoparticulate systems for macrophage targeting [J].
Chellat, F ;
Merhi, Y ;
Moreau, A ;
Yahia, L .
BIOMATERIALS, 2005, 26 (35) :7260-7275
[7]   The potential environmental impact of engineered nanomaterials [J].
Colvin, VL .
NATURE BIOTECHNOLOGY, 2003, 21 (10) :1166-1170
[8]   Alginate/chitosan microparticles for tamoxifen delivery to the lymphatic system [J].
Coppi, G. ;
Iannuccelli, V. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 367 (1-2) :127-132
[9]   Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells [J].
Das, Ratul Kumar ;
Kasoju, Naresh ;
Bora, Utpal .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2010, 6 (01) :153-160
[10]  
Davis M.E., 2006, Nanotech L Bus, V3, P255
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