Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo-[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl-iminium Chemistry

被引：24

作者：

El Blidi, Lahssen ^{[1
,2
]}

Namoune, Aurelie ^{[1
]}

Bridoux, Alexandre ^{[1
]}

Nimbarte, Vijaykumar D. ^{[1
]}

Lawson, Ata Martin ^{[1
]}

Comesse, Sebastien ^{[1
]}

Daich, Adam ^{[1
]}

机构：

[1] Univ Havre, Chim Lab, EA 3221, UFR Sci & Tech,URCOM,CNRS FR INC3M 3038, F-76063 Le Havre, France

[2] King Saud Univ, Coll Engn, Dept Chem Engn, Riyadh 11421, Saudi Arabia

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 22期

关键词：

N-acyliminium; aromathecins; rosettacin; aryl radical cyclization; enamide; topoisomerase I (Topo1); 6-MEMBERED HETEROCYCLIC RINGS; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; CONCISE SYNTHESIS; MAPPICINE KETONE; 22-HYDROXYACUMINATINE; ACID; 14-AZACAMPTOTHECIN; PROTOBERBERINE; ISOCOUMARIN;

D O I：

10.1055/s-0034-1378811

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and effective approach to the synthesis of the topoisomerase I inhibitor isoindolo[2,1-b] isoquinolin-7(5H)-one and the alkaloid rosettacin belonging to the aromathecin family is presented. The key step of this sequence, which resulted in the formation of a five-membered ring, was the aryl radical cyclization of enamides generated using N-acyliminium chemistry.

引用

收藏

页码：3583 / 3592

页数：10

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