Acute symptomatic seizures and hippocampus damage: DWI and MRS findings

被引：47
作者：
Parmar, Hemant
Lim, Shih-Hui
Tan, Nigel C. K.
Lim, C. C. Tchoyoson
机构：
[1] Natl Inst Neurosci, Dept Neuroradiol, Singapore 308433, Singapore
[2] Natl Inst Neurosci, Dept Neurol, Singapore 308433, Singapore
[3] Univ Michigan, Div Neuroradiol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
[5] Natl Univ Singapore, Dept Diagnost Radiol, Singapore 117548, Singapore
来源：
NEUROLOGY | 2006年 / 66卷 / 11期
关键词：
D O I：
10.1212/01.wnl.0000218207.18707.f4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient ( ADC) in all patients, with corresponding lactate detected on MRS in six patients and EEG seizure activity in nine patients. On follow-up, the atrophic hippocampus had an increased ADC in six patients. DWI and MRS may predict development of hippocampal sclerosis.
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收藏
页码：1732 / 1735
页数：4
相关论文
共 10 条
  • [1] Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
    Bengzon, J
    Kokaia, Z
    Elmer, E
    Nanobashvili, A
    Kokaia, M
    Lindvall, O
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) : 10432 - 10437
  • [2] Seizure-associated abnormalities in epilepsy: Evidence from MR imaging
    Briellmann, RS
    Wellard, RM
    Jackson, GD
    [J]. EPILEPSIA, 2005, 46 (05) : 760 - 766
  • [3] Hippocampal sclerosis following brief generalized seizures in adulthood
    Briellmann, RS
    Newton, MR
    Wellard, RM
    Jackson, GD
    [J]. NEUROLOGY, 2001, 57 (02) : 315 - 317
  • [4] Seizure-induced neuronal injury - Human data
    Duncan, JS
    [J]. NEUROLOGY, 2002, 59 (09) : S15 - S20
  • [5] Acute diffusion abnormalities in the hippocampus of children with new-onset seizures: the development of mesial temporal sclerosis
    Farina, L
    Bergqvist, C
    Zimmerman, RA
    Haselgrove, J
    Hunter, JV
    Bilaniuk, LT
    [J]. NEURORADIOLOGY, 2004, 46 (04) : 251 - 257
  • [6] NEURON LOSS LOCALIZES HUMAN TEMPORAL-LOBE EPILEPSY BY IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
    HUGG, JW
    LAXER, KD
    MATSON, GB
    MAUDSLEY, AA
    WEINER, MW
    [J]. ANNALS OF NEUROLOGY, 1993, 34 (06) : 788 - 794
  • [7] Kim JA, 2001, AM J NEURORADIOL, V22, P1149
  • [8] MRI, 1H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity
    Lazeyras, F
    Blanke, O
    Zimine, I
    Delavelle, J
    Perrig, SH
    Seeck, M
    [J]. NEUROLOGY, 2000, 55 (11) : 1677 - 1682
  • [9] Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions
    VanLandingham, KE
    Heinz, ER
    Cavazos, JE
    Lewis, DV
    [J]. ANNALS OF NEUROLOGY, 1998, 43 (04) : 413 - 426
  • [10] CHANGES IN WATER DIFFUSION AND RELAXATION PROPERTIES OF RAT CEREBRUM DURING STATUS EPILEPTICUS
    ZHONG, J
    PETROFF, OAC
    PRICHARD, JW
    GORE, JC
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1993, 30 (02) : 241 - 246
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