Supermolecule-assisted imaging of low-molecular-weight quaternary-ammonium compounds by MALDI-MS of their non-covalent complexes with cucurbit[7]uril

被引：3

作者：

Chen, Di ^{[1
,2
]}

Han, Jun ^{[1
,3
]}

Yang, Juncong ^{[1
]}

Schibli, David ^{[1
]}

Zhang, Zhenzhong ^{[2
]}

Borchers, Christoph H. ^{[4
,5
,6
,7
]}

机构：

[1] Univ Victoria, Genome British Columbia Prote Ctr, Victoria, BC V8Z 7X8, Canada

[2] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[3] Univ Victoria, Div Med Sci, Victoria, BC V8P 5C2, Canada

[4] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8P 5C2, Canada

[5] McGill Univ, Jewish Gen Hosp, Gerald Bronfman Dept Oncol, Montreal, PQ H3T 1E2, Canada

[6] McGill Univ, Jewish Gen Hosp, Segal Canc Prote Ctr, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[7] Skolkovo Inst Sci & Technol, Ctr Computat & Data Intens Sci & Engn, Moscow 121205, Russia

来源：

RSC ADVANCES | 2020年 / 10卷 / 56期

关键词：

BRAIN-TISSUE; SUPRAMOLECULAR CHEMISTRY; NEUROTRANSMITTERS;

D O I：

10.1039/d0ra04604c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cucurbit[7]uril was used to form non-covalent complexes with low-molecular-weight quaternary-ammonium compounds for their indirect analysis by MALDI-MS. By shifting the ion signals to a higher and interference-free mass region, the distributions of neurine, choline, and phosphocholine in rat brain were visualized by MALDI imaging with high selectivity and good sensitivity.

引用

页码：34261 / 34265

页数：5