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China Med Univ, Dept Cell Biol, Key Lab Cell Biol, Natl Hlth Commiss PRC,Minist Educ PRC, Shenyang 110122, Peoples R China China Med Univ, Dept Cell Biol, Key Lab Cell Biol, Natl Hlth Commiss PRC,Minist Educ PRC, Shenyang 110122, Peoples R China