Complex of C60 Fullerene with Doxorubicin as a Promising Agent in Antitumor Therapy

被引:45
|
作者
Prylutska, Svitlana V. [1 ]
Skivka, Larysa M. [1 ]
Didenko, Gennadiy V. [2 ]
Prylutskyy, Yuriy I. [1 ]
Evstigneev, Maxim P. [3 ]
Potebnya, Grygoriy P. [2 ]
Panchuk, Rostyslav R. [4 ]
Stoika, Rostyslav S. [4 ]
Ritter, Uwe [5 ]
Scharff, Peter [5 ]
机构
[1] Taras Shevchenko Natl Univ Kyiv, UA-01601 Kiev, Ukraine
[2] NASU, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine
[3] Belgorod State Univ, Belgorod 308015, Russia
[4] NAS Ukraine, Inst Cell Biol, UA-79005 Lvov, Ukraine
[5] Tech Univ Ilmenau, Inst Chem & Biotechnol, D-98693 Ilmenau, Germany
来源
NANOSCALE RESEARCH LETTERS | 2015年 / 10卷
关键词
C-60; fullerene; Doxorubicin; Antitumor effect; Antimetastatic effect; Immune response;
D O I
10.1186/s11671-015-1206-7
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The main aim of this work was to evaluate the effect of doxorubicin in complex with C-60 fullerene (C-60 + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C-60 + Dox complex action. We found that volume of tumor from mice treated with the C-60 + Dox complex was 1.4 times less than that in control untreated animals. The number of metastatic foci in lungs of animals treated with C-60 + Dox complex was two times less than that in control untreated animals. Western blot analysis of tumor lysates revealed a significant decrease in the level of heat-shock protein 70 in animals treated with C-60 + Dox complex. Moreover, the treatment of tumor-bearing mice was accompanied by the increase of cytotoxic activity of immune cells. Thus, the potential mechanisms of antitumor effect of C-60 + Dox complex include both its direct action on tumor cells by inducing cell death and increasing of stress sensitivity and an immunomodulating effect. The obtained results provide a scientific basis for further application of C-60 + Dox nanocomplexes as treatment agents in cancer chemotherapy.
引用
收藏
页码:1 / 7
页数:7
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