Effect of lumbo-peritoneal shunt surgery on neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus

被引：20
作者：
Kanemoto, Hideki [1 ]
Kazui, Hiroaki [1 ]
Suzuki, Yuldko [1 ]
Sato, Syunsuke [1 ]
Kishima, Haruhiko [2 ]
Yoshimine, Toshiki [2 ]
Yoshiyama, Kenji [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Psychiat, D3 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Neurosurg, D3 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2016年 / 361卷
关键词：
Idiopathic normal pressure hydrocephalus; Neuropsychiatric symptoms; Caregiver burden; Apathy; Depression; Lumbo-peritoneal shunt surgery; CEREBRAL-BLOOD-FLOW; FRONTAL ASSESSMENT BATTERY; WHITE-MATTER LESIONS; MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; CAREGIVER BURDEN; FRONTOTEMPORAL DEMENTIA; URINARY DYSFUNCTION; DISORDERS; APATHY;
D O I：
10.1016/j.jns.2016.01.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: Patients with idiopathic normal pressure hydrocephalus (iNPH) have neuropsychiatric symptoms that could affect patients' quality of life and caregiver burden. In this study, we assessed the effect of lumbo-peritoneal (L-P) shunt surgery on neuropsychiatric symptoms and the association between neuropsychiatric symptoms and caregiver burden after L-P shunt surgery. Methods: We recruited 22 iNPH patients who had L-P shunt surgery and who were followed up for 3 months after surgery. Neuropsychiatric symptoms and caregiver burden were evaluated with the Neuropsychiatric Inventory (NPI) and Zarit Burden Interview (ZBI), respectively, before and 3 months after surgery. We evaluated the changes of NPI and ZBI and the association between the changes in these 2 scores and the triad symptoms. Results: NPI total, apathy, and depression scores significantly decreased after surgery. The improvement in NPI total, apathy, disinhibition, and irritability scores after surgery were significantly and positively associated with improvement in ZBI score after surgery. Improvement in NPI apathy score was significantly associated with improvement in Frontal Assessment Battery score after surgery. Conclusion: L-P shunt surgery was effective in reducing not only the triad symptoms but also the neuropsychiatric symptoms, and the improved neuropsychiatric symptoms might decrease caregiver burden for iNPH patients. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：206 / 212
页数：7
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