Only Two Ways to Achieve Perfection

被引：11

作者：

Artyukhin, Alexander B. ^{[1
]}

Wu, Lani F. ^{[1
]}

Altschuler, Steven J. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Simmons Canc Ctr, Green Ctr Syst Biol, Dept Pharmacol, Dallas, TX 75390 USA

来源：

CELL | 2009年 / 138卷 / 04期

关键词：

CELL;

D O I：

10.1016/j.cell.2009.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establish perfect adaptation, the ability to reset after perturbation. Surprisingly, the answer is just two.

引用

页码：619 / 621

页数：3

共 9 条

[1] Alon U., 2007, An Introduction to Systems Biology
[2] On the spontaneous emergence of cell polarity
Altschuler, Steven J.
Angenent, Sigurd B.
Wang, Yanqin
Wu, Lani F.
[J]. NATURE, 2008, 454 (7206) : 886 - U41
[3] Feedback loops shape cellular signals in space and time
Brandman, Onn
Meyer, Tobias
[J]. SCIENCE, 2008, 322 (5900) : 390 - 395
[4] A case study of evolutionary computation of biochemical adaptation
Francois, Paul
Siggia, Eric D.
[J]. PHYSICAL BIOLOGY, 2008, 5 (02)
[5] Combinatorial synthesis of genetic networks
Guet, CC
Elowitz, MB
Hsing, WH
Leibler, S
[J]. SCIENCE, 2002, 296 (5572) : 1466 - 1470
[6] Ingalls B.P., 2006, SYSTEM MODELING CELL, P243
[7] Do motifs reflect evolved function?-No convergent evolution of genetic regulatory network subgraph topologies
Knabe, Johannes F.
Nehaniv, Chrystopher L.
Schilstra, Maria J.
[J]. BIOSYSTEMS, 2008, 94 (1-2) : 68 - 74
[8] Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
Tyson, JJ
Chen, KC
Novak, B
[J]. CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) : 221 - 231
[9] Robust perfect adaptation in bacterial chemotaxis through integral feedback control
Yi, TM
Huang, Y
Simon, MI
Doyle, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) : 4649 - 4653

← 1 →