Cardiopulmonary effects of dexmedetomidine in goats and sheep anaesthetised with sevoflurane

被引:24
作者
Kutter, A. P. N.
Kastner, S. B. R.
Bettschart-Wolfensberger, R.
Huhtinen, M.
机构
[1] Univ Zurich, Vetsuisse Fac, Sect Vet Anaesthesia, Equine Clin, CH-8057 Zurich, Switzerland
[2] Orion Corp Orion, Pharma Anim Hlth, FIN-20101 Turku, Finland
关键词
D O I
10.1136/vr.159.19.624
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
In sheep, alpha(2)-agonists can induce severe hypoxaemia. In goats, reports on changes in oxygenation are inconsistent. The aim of this study was to compare the cardiopulmonary effects of dexmedetomidine in six goats and four sheep anaesthetised with sevoflurane and maintained at approximately 1 minimal alveolar concentration. The animals were ventilated mechanically and held in an upright position to minimise the influence of positioning on pulmonary function. After baseline cardiopulmonary measures, 2 mu g/kg dexmedetomidine was injected intravenously over one minute, and measurements were made for 120 minutes. In both species, respiratory resistance, alveolar dead space and shunt fraction increased and thoracic compliance decreased significantly; arterial, pulmonary arterial, pulmonary capillary wedge and central venous pressures increased and heart rate and cardiac output decreased significantly. Arterial oxygen tension decreased significantly, with no significant difference between the goats and sheep. Wide interindividual differences were observed in both the goats (mean [sd] 144 [149-1] mmHg range 54.8 to 443.7 mmHg) and sheep (mean [sd] 129-8 [132-1] mmH& range 33-7 to 352-8 mmHg), but the cardiovascular and respiratory changes were similar in the two species.
引用
收藏
页码:624 / +
页数:6
相关论文
共 46 条
[1]   VARIABILITY OF HYPOXIC PULMONARY VASOCONSTRICTION IN SHEEP - ROLE OF PROSTAGLANDINS [J].
AHMED, T ;
OLIVER, W ;
WANNER, A .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1983, 127 (01) :59-62
[2]  
AZIZ M A, 1978, Zentralblatt fuer Veterinaermedizin Reihe A, V25, P173
[3]   Impairment of gas exchange due to alveolar oedema during xylazine sedation in sheep; absence of a free radical mediated inflammatory mechanism [J].
Bacon, PJ ;
Jones, JG ;
Taylor, P ;
Stewart, S ;
Wilson-Nunn, D ;
Kerr, M .
RESEARCH IN VETERINARY SCIENCE, 1998, 65 (01) :71-75
[4]  
BOLLER J, 2004, P ASS VET AN AUT M V, P80
[5]  
Caulkett NA, 1996, J ZOO WILDLIFE MED, V27, P217
[6]  
Celly CS, 1999, J PHARMACOL EXP THER, V289, P712
[7]  
Celly CS, 1999, AM J VET RES, V60, P154
[8]   Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha(2) adrenoceptor agonist ST-91 in conscious sheep [J].
Celly, CS ;
McDonell, WN ;
Black, WD ;
Young, SS .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1997, 20 (06) :472-478
[9]   The comparative hypoxaemic effect of four alpha(2) adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep [J].
Celly, CS ;
McDonell, WN ;
Young, SS ;
Black, WD .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1997, 20 (06) :464-471
[10]   XYLAZINE - A NEW SEDATIVE FOR HORSES AND CATTLE [J].
CLARKE, KW ;
HALL, LW .
VETERINARY RECORD, 1969, 85 (19) :512-&