A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab

被引：15

作者：

Jung, Ki Hwan

Sung, Hwa Jung

Lee, Ju-Han ^{[2
]}

Lee, Ki Yeol ^{[3
]}

Shin, Jae Seung ^{[4
]}

Kim, Kyung Min ^{[5
]}

Kim, Young-Sik ^{[2
]}

Shin, Chol

Kim, Je Hyeong ^{[1
]}

机构：

[1] Korea Univ, Ansan Hosp, Dept Internal Med, Div Pulm Sleep & Crit Care Med, Ansan 425707, South Korea

[2] Korea Univ, Ansan Hosp, Dept Pathol, Ansan 425707, South Korea

[3] Korea Univ, Ansan Hosp, Dept Radiol, Ansan 425707, South Korea

[4] Korea Univ, Ansan Hosp, Dept Thorac & Cardiovasc Surg, Ansan 425707, South Korea

[5] Korea Univ, Ansan Hosp, Dept Nucl Med, Ansan 425707, South Korea

来源：

CHEMOTHERAPY | 2009年 / 55卷 / 05期

关键词：

Lymphomatoid granulomatosis; Combination chemotherapy; Monoclonal antibodies; NON-HODGKINS-LYMPHOMA; THERAPY; DISEASE; CHOP; PET;

D O I：

10.1159/000237745

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells. LYG most commonly affects the lung but can also involve other extrapulmonary sites. Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. It can mimic various infectious diseases, vasculitis or metastatic malignancy and is difficult to be diagnosed clinically. Standard treatment for LYG has not yet been established. Despite combination chemotherapy, the overall prognosis is poor. Recently, anti-CD20 monoclonal antibody, rituximab, has been used to treat LYG. We report the case of a 70-year-old male patient with pulmonary LYG, who showed rapid remission of the disease after combination chemotherapy with rituximab. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：386 / 390

页数：5

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